Activating Stem Cells of ALS Patients With Valproic Acid

Octav Cristea — 2007-12-18T21:01:44-05:00

Sodium Valproate belongs to a class of compounds called “histone deacetylase inhibitors”, which are known for ability to “desilence” the genome, allowing expression of genes that under normal situations would not be expressed [1]. This “desilencing” activity is believed to allow for increasing ability of stem cells to propagate in vitro without differentiating [2, 3]. Clinically, valproic acid is an established treatment for epileptic seizures and...

Obviousness and Biotechnology

Teodor Danielyan — 2006-11-29T21:25:20-05:00

Introduction

Due to the substantial upfront investment needed for development of therapeutics (transition from “bench to bedside” often costs > $500 million), the biotechnology industry as a whole is highly dependent on the effective working of the patent system. In this paper we will describe a very important case in front of the Supreme Court that can potentially alter the criteria of patentability, thereby making a significant impact on our industry.

Immunological Control of Neoplasia - Chapter 4

Christine Ichim — 2006-11-02T14:16:41-05:00

Chapter 4 Immune Interactions with Chronic Myeloid Leukemia (CML)

In the previous chapters the case was made for the ability of immune response to effect tumour growth and for the ability of the tumour to protect its self from immune attack. This base of knowledge will now be applied to CML in hopes of providing future research directions. CML was chosen due to several factors that suggest an important role...

Immunological Control of Neoplasia - Chapter 3

Christine Ichim — 2006-11-02T14:14:19-05:00

Chapter 3 Immune Suppression in Cancer

Previous theories about cancer interactions with the immune system attributed a primary role for the immune system in controlling and stopping the growth of neoplasia. The concept of immune surveillance, proposed by Thomas and Burnet, advocates that immune cells are patrolling the host for mutations. Once mutations have been detected, the abnormal cells are destroyed. The theory of immune surveillance, and supporting...

Immunological Control of Neoplasia - Chapter 2

Christine Ichim — 2006-11-02T14:10:02-05:00

Chapter 2 Components of Immune Response

Overview of the Antitumour Response

The immune system, according to Janis Kuby is "a remarkably adaptive defense system that has evolved in vertebrates to protect them from invading microorganisms and cancer" (156). Although a comprehensive review of the immune response to tumours is beyond the scope of this work, the typical immune response to tumours will be delineated. For reviews of this...

Immunological Control of Neoplasia - Chapter 1

Christine Ichim — 2006-11-02T13:58:20-05:00

*Immunological Control of Neoplasia* Christine V. Ichim and Thomas E. Ichim Copyright � 1998 by Christine V Ichim and Thomas E Ichim All rights reserved, no part of this work may be reproduced, stored in a retrieval system, or transmitted by any means, electronic,mechanical, photocopying or otherwise, without the prior written permission of Rapoport Publishing. Rapoport Publishing 16 Miehm Place Kitchener, Ontario Canada N2H 2K9 ISBN...

Immunological Implications of Androgen Ablation

Yan Lin — 2006-10-24T23:52:39-05:00

Introduction

There is a great need for novel therapeutic approaches to prostate cancer, the second
leading cause of cancer related deaths in American men (1). In this hypothesis paper we
evaluate immunological implications of hormonal manipulations in several models
systems and try to extrapolate the findings to the immunological impact of androgen
ablation in metastatic prostate cancer patients. The essence of our hypothesis lies...

Dendritic Cell Control of Immunity

Octav Cristea — 2006-10-24T23:47:16-05:00

Introduction

The purpose of this paper is to review evidence for the ability of dendritic cells (DC) to
induce T cell activation or T cell tolerance with emphasize on cancer. DC are the most
potent of antigen presenting cells (APC), having the ability to activate naïve and memory
T cells about 100-fold higher than macrophages (1, 2). These functions have prompted
investigation of mechanisms by which DC promote immune responses...

Immune Modulation for Treatment of Cancer

Hamid Izadi — 2006-10-24T23:43:53-05:00

Natural Antibodies

This type of antibody is an innate form of immune response, which is produced by a
specialized type of B cell called the B-1 cell (1). These antibodies recognize molecular
targets that evolutionarily been a “danger” to the host such as bacterial antigens (2,3). In
addition, it is natural antibodies which cause hyperacute rejection of xenotransplants (4).
Such antibodies have been described against...

Chemotherapy and Immunological Aspects

Kornel Kusznieruk — 2006-10-24T23:39:44-05:00

There are four main uses of chemotherapy, these are:

a) Induction. This refers to using the therapy as a frontline treatment for a cancer in
which no other alternative exists.

b) Adjunct or Adjuvant. This involves using chemotherapy to prevent reoccurrence after
another primary treatment was applied. Usually, adjunct therapy is used after surgery or
radiation.

c) Neoadjuvant. This treatment is performed before an intervention...

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