StemCellPatents.com News

Immunology Instead of Stem Cells: Vaccine for Alzheimer's

StemCellPatents.com — 2008-05-11T17:30:29-05:00

Huntington Beach, CA -

A recent paper from Dr. Agadjanyan's group at the Institute of Molecular Medicine (Movsesyan et al. Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy. PLoS ONE 2008 May 7;3(5):e2124) reports the successful treatment of a mouse model of Alzheimer's using DNA vaccination against amyloid protein peptides.

Previously clinical trials were conducted using vaccination...

Interview with Novocell CEO Alan Lewis

StemCellPatents.com — 2008-04-29T23:38:49-05:00

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In this StemCellPatents.com interview, our special guest interviewer, Thomas Ichim, CEO of Medistem, speaks with Alan Lewis, CEO of Novocell, regarding the company's advances towards curing diabetes. This interview examines many aspects of Novocell which include: the history of Novocell and how the company was formed; their strategy for being a...

FGF-1 Gene Therapy Double Blind Trial

StemCellPatents.com — 2008-04-23T19:50:50-05:00

Münster, Germany -

Understanding and manipulating the formation of new blood vessels, a process called angiogenesis, has been one of the highly sought-after goals of the biotechnology industry. One the one hand, inhibition of angiogenesis is desirable in cancer, since tumors need new blood vessels to stay alive. On the other hand, angiogenesis stimulation could be a beneficial treatment for diseases such as ischemic heart failure and other types of conditions...

Parathyroid hormone mobilization and limb ischemia

StemCellPatents.com — 2008-04-23T11:30:14-05:00

Naples, Italy -

The administration of bone marrow stem cells into ischemic muscles for treatment of critical limb ischemia is currently being performed in clinical trials, with results demonstrating stimulation of angiogenesis and functional improvement. Given that a substantial amount of the angiogenic response seems to be dependent on endogenous stem cell mobilization, one interesting idea is to mobilize endogenous...

Menstrual Blood Stem Cells Part 2

StemCellPatents.com — 2008-04-22T03:38:18-05:00

Tokyo, Japan -

It was previously reported by the company Medistem (mdsm.ob) that a population of multipotent stem cells exist in menstrual blood. These cells, which Medistem termed "endometrial regenerative cells" appear to possess some of the properties of mesenchymal stem cells, such as expression of CD90 and CD105, as well as are capable of differentiating into 9 major tissues of the...

Expanding Hematopoietic Stem Cells by Removing Inhibitors

StemCellPatents.com — 2008-04-20T15:22:22-05:00

The desire to expand hematopoietic stem cells is not only a basic research accomplishment but would allow for widespread use of autologous stem cells, as well as expand the utilization of cord blood stem cells which are usually of concern due to the relatively low stem cell content.

Various methods of expanding hematopoietic stem cells exist, for example, treatment with histone deacetylase inhibitors, culture in various cytokine...

"I need blood" says the embryoid body

StemCellPatents.com — 2008-04-13T15:39:22-05:00

Tokyo, Japan -

Embryonic stem cells have a very high potential to generate various tissues, a potential so high that it actually serves as a drawback in some senses. See, embryonic stem cells, when grown in floating cultures form embryoid bodies, and in these embryoid bodies the embryonic stem cell starts differentiating into a wide variety of different tissues spontaneously.

There are patents out there that teach people to...

Stem Cell Cytokines Preventing Ischemia Reperfusion

StemCellPatents.com — 2008-04-12T21:32:30-05:00

Osaka, Japan -

Granulocyte colony stimulating factor (G-CSF) is one of the largest selling products of the biotechnology industry. Approved uses of this recombinant cytokine include stimulation of neutrophil production after chemotherapy or bone marrow transplantation. Another use is in mobilizing the hematopoietic stem cells to leave the bone marrow and enter peripheral circulation.

Since G-CSF has been...

Treating back pain with mesenchymal stem cells

StemCellPatents.com — 2008-04-12T14:52:30-05:00

Pittsburgh, Pennsylvania -

Vertebral disc degeneration is a major cause of suffering internationally. Although various interventions exist, such as disc replacement and surgical fusion, these have numerous long-term limitations such as need for resurgery, degeneration of the adjacent disc, and relapse of pain. One exciting method of treating disc degeneration involves the administration of stem cells into the nucleus pulposus in order to reverse...

Clinical trial for diabetes using autologous cord blood

StemCellPatents.com — 2008-04-01T20:37:06-05:00

Gainsville, Florida -

Autologous cord blood has received some recent media for its use in treatment of cerebral palsy. Other groups have reported the use of allogeneic cord blood to have positive effects for conditions other than hematopoietic disorders, even in absence of immune suppression. Accordingly there seems to be a trend towards more and more researchers and clinicians to start...