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Activating Stem Cells of ALS Patients With Valproic Acid

The recent funding of Fate Therapeutics as a company dedicated to identification of pharmacological stem cell activators is a great step for the industry. Essentially, the concept of the company is that one day one will be able to activate one's own stem cells through taking various chemical compounds. This concept is not new, companies such as Stem Cell...

Affiliation: University of Waterloo

Obviousness and Biotechnology

Of the three requirements for patentability, the notion of “obviousness” is the most elusive. The case of KSR v Teleflex that is currently in front of the Supreme Court is the first revisitation of the question of “obviousness” since Sakraida in 1976. Under discussion is the issue if whether obviousness should be decided by what is apparent to...

Author: Teodor Danielyan
Affiliation: University of Calgary, Canada
Date Published: Wednesday November 29th, 2006

Immunological Implications of Androgen Ablation

This paper describes some mechanisms by which androgen ablation is useful for the treatment of prostate cancer, these mechanisms are immunological.

Author: Yan Lin
Affiliation: Hunan University, China
Date Published: Tuesday October 24th, 2006

Dendritic Cell Control of Immunity

This paper describes the dendritic cell and its critical role in activation and suppression of immune responses.

Author: Octav Cristea
Affiliation: University of Waterloo
Date Published: Tuesday October 24th, 2006 1 Comment

Immune Modulation for Treatment of Cancer

Described is a method of immunomodulation cancer patients, according to some ideas
proposed in the 1960s which I have tried to bring up to date. According to this novel
treatment method the patient is treated with individualized doses of three biological
solutions: 1) Natural Antibody, 2) Purified Complement, and 3) Alpha-2 macroglobulin.
Natural antibodies are...

Author: Hamid Izadi
Affiliation: University of Waterloo
Date Published: Tuesday October 24th, 2006

Chemotherapy and Immunological Aspects

Here we overview chemotherapy and some of its immunological consequences.

Author: Kornel Kusznieruk
Affiliation: University of Western Ontario
Date Published: Tuesday October 24th, 2006

Tumor Hypoxia and Ozone Therapy

This paper describes the importance of increasing oxygen content in tumors and provides some possible ways of doing this.

Author: Kornel Kusznieruk
Affiliation: University of Western Ontario
Date Published: Tuesday October 24th, 2006 1 Comment

Tumor Antigens

The rationale for immunotherapy, is dependent on the idea that
cancer must be recognised by the immune system. Cancer cells are derived from the
patient’s own tissue, therefore there has been some reluctance in believing that the
immune response can effectively control or even eradicate neoplasia. In the age of
molecular biology, great advances have occurred...

Author: Kornel Kusznieruk
Affiliation: University of Western Ontario
Date Published: Tuesday October 24th, 2006

De-repression of Anti-Cancer Immunity by N-Acetylcysteine

This paper describes a method of treating cancer through de-repression of anticancer immune responses using a drug that is already in clinical use for treatment of acetaminophen overdose.

Author: Emiliano Rapoport
Affiliation: Andromeda Biotherapeutics
Date Published: Friday October 20th, 2006

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