Category: Neural (23)
ALS Therapy by Stem Cells
Treatment of MS by Stem Cells
HIF involved in mesenchymal to neural differentiation
Caen cedex, France - The identification of molecular signals associated with cellular differentiation is important from a drug development perspective. Recently, a paper was published describing mechanisms of mesenchymal stem cell differentiation to neural cells (Pacary et al. Crosstalk between HIF-1 and ROCK pathways in neuronal...
Coaxing ES cells to neurons
Hong Kong, China - Numerous groups are currently working on protocols for induction of differentiation of embryonic stem cells into specific cell types that are therapeutically useful. One logical method of stimulating differentiation involves co-culture with cells that would appear to have an "inductive" effect on the undifferentiated cell. On the one hand, numerous groups use methods...
HSP antiinflammatory
San Francisco, California - Heat shock proteins are conventionally thought of as molecular chaperones that function intracellularly. Immunologically, heat shock proteins are known to bind various tumor antigens and can be used as adjuvants. The properties of adjuvants include non-specific activation of innate immunity. It was found that various heat shock proteins stimulate macrophage and...
Neural proliferation after injury
Miami, Florida - Although it is reported that the brain can repair itself after injury, detailed examination of this is still somewhat lacking. In a nicely designed study (Urrea et al. Widespread cellular proliferation and focal neurogenesis after traumatic brain injury in the rat. Restor Neurol Neurosci. 2007;25(1):65-77), proliferation of various brain areas was assessed following...
Importance of Injury in Stem Cell Neurorepair
Milano, Italy - In various pathological conditions injured tissue attracts endogenous stem cells through release of various factors. This is known, for example, in the area of myocardial infarction where circulating levels of stem cells increase in the peripheral blood of patients after heart attacks. Theoretically, the idea is that the ischemia and tissue damage release systemic factors...
In vitro ALS model
Cambridge, Massachusetts - Generation of in vitro models of human diseases allows utilization of high-throughput screening, as well as isolated molecular dissection of events in order to identify targets for intervention. A recent paper (Di Giorgio et al. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model Nat Neurosci...
Neupogen: From White Cell to White Matter
Chiba, Japan - The clinical use of G-CSF (Neupogen) has allowed for mobilization of stem cells in the peripheral blood stem cell transplant setting, as well as a means of accelerating hematopoietic recovery in a variety of settings. A recent paper suggests that mobilization of stem cells using G-CSF may be useful not only for hematopoietic indications but also for inducing repair post...
Sugar in the brain
Tokyo, Japan - It is known that a wide variety of factors are capable of inducing neurogenesis in the adult brain. For example, post-stroke neurogenesis is known to be at least partially dependent on eryothropoietin signaling (Tsai et al. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006 Jan 25;26(4):1269-74.)Saturday March 17th, 2007 @ 15:25:29 EST