Category: Use (71)
Mobilized Stem Cells for Peripheral Artery Disease
Hangzhou, China -
The use of autologous bone marrow stem cells for peripheral artery disease is occuring in the US as part of clinical trials. The rational is that insertion of stem cells into ischemic muscle leads to angiogenesis either through the endothelial precursor... Erlangen, Germany -
Although mesenchymal stem cells are primarily known for their differentiation abilities, the first clinical trials, and most likely BLA grantings, will be for immune modulation by these cells in the conditions of graft versus host disease and Crohn's disease.
In the same way that
T regulatory cell control of bone resorption
Bone marrow stem cells in pulmonary hypertension
New Orleans, Louisiana - Adult stem cells have been used clinically in treatment of heart failure, liver failure, and advanced peripheral artery disease. One exciting possible use of stem cells is in the treatment of...
Rapamycin turns stops Th17 but promotes Treg
Frederick, Maryland - Although mesenchymal stem cells are currently used in an allogeneic manner clinically, the question of whether they are truly tolerogenic is still debated. Other stem cell types such as CD34 or embryonic stem cells may...
Allogeneic Serum is OK for Mesenchymal Stem Cell Culture
Stockholm, Sweden - The use of mesenchymal stem cells as a therapeutic is now a clinical reality. US companies such as Osiris Therapeutics are in Phase III of clinical trials, whereas clinics outside of the US such as Cellmedicine are offering such therapies as a fee for service. One of the problems with growing stem cells has always been the issue of fetal...
TLR3 and 4 Ligation Abrogates Mesenchymal Stem Cell Immune Suppression
Florence, Italy - Mesenchymal stem cells are known to suppress immune responses in antigen specific and non-specific ways. In a recent paper (Liotta et al. TLR3 and TLR4 are Expressed by Human Bone Marrow-Derived...
Sheep with bad kidneys: intra-renal arterial mesenchymal stem cell administration
Paris, France - Bone marrow derived mesenchymal stem cells are most likely going to be the first stem cell type approved in the US for regenerative, non-hematopoietic purposes. Currently the company Osiris Therapeutics is leading the way by performing pivotal Phase III trials using these cells. The use of mesenchymal stem cells for treatment of ischemic kidney...
MyoD Deficiency Helps Muscle Stem Cells
Minneapolis, MN - MyoD is a basic helix-loop-helix myogenic transcription factor involved in differentiation of muscle cells. In a recent paper (Asakura et al. Increased survival of muscle stem cells lacking the MyoD gene after transplantation into regenerating skeletal muscle.Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16552-7) scientists wanted to determine whether muscle stem cells...
IVIG treats mouse model of multiple sclerosis by Treg upregulation
Paris, France - It has previously been reported that immunoglobulins play a fundamental role in stem cell mobilization. It is also known that intravenous immunoglobulin (IVIG) possesses numerous anti-inflammatory properties. In a recent paper (Ephrem et al. Expansion of CD4+CD25+ regulatory T cells by...
New T regulatory marker found: Folate Receptor 4
Kyoto, Japan - One of the exciting uses of stem cells is suppression of inflammatory reactions. In other words, various types of stem cells, such as mesenchymal stem cells, are known to possess membrane-bound molecules that inhibit T cell activation, or soluble products such as HLA-G5 which also inhibits T cell activation. The immune system can be regulated by...