Category: Use (79)
Bone marrow stem cells in pulmonary hypertension
New Orleans, Louisiana - Adult stem cells have been used clinically in treatment of heart failure, liver failure, and advanced peripheral artery disease. One exciting possible use of stem cells is in the treatment...
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Rapamycin turns stops Th17 but promotes Treg
Frederick, Maryland - Although mesenchymal stem cells are currently used in an allogeneic manner clinically, the question of whether they are truly tolerogenic is still debated. Other stem cell types such as CD34 or embryonic stem cells may...
Allogeneic Serum is OK for Mesenchymal Stem Cell Culture
Stockholm, Sweden - The use of mesenchymal stem cells as a therapeutic is now a clinical reality. US companies such as Osiris Therapeutics are in Phase III of clinical trials, whereas clinics outside of the US such as Cellmedicine are offering such therapies as a fee for service. One of the problems with growing stem cells has always been the issue of fetal...
TLR3 and 4 Ligation Abrogates Mesenchymal Stem Cell Immune Suppression
Florence, Italy - Mesenchymal stem cells are known to suppress immune responses in antigen specific and non-specific ways. In a recent paper (Liotta et al. TLR3 and TLR4 are Expressed by Human Bone Marrow-Derived...
Sheep with bad kidneys: intra-renal arterial mesenchymal stem cell administration
Paris, France - Bone marrow derived mesenchymal stem cells are most likely going to be the first stem cell type approved in the US for regenerative, non-hematopoietic purposes. Currently the company Osiris Therapeutics is leading the way by performing pivotal Phase III trials using these cells. The use of mesenchymal stem cells for treatment of ischemic kidney...
MyoD Deficiency Helps Muscle Stem Cells
Minneapolis, MN - MyoD is a basic helix-loop-helix myogenic transcription factor involved in differentiation of muscle cells. In a recent paper (Asakura et al. Increased survival of muscle stem cells lacking the MyoD gene after transplantation into regenerating skeletal muscle.Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16552-7) scientists wanted to determine whether muscle stem cells...
IVIG treats mouse model of multiple sclerosis by Treg upregulation
Paris, France - It has previously been reported that immunoglobulins play a fundamental role in stem cell mobilization. It is also known that intravenous immunoglobulin (IVIG) possesses numerous anti-inflammatory properties. In a recent paper (Ephrem et al. Expansion of CD4+CD25+ regulatory T cells by...
New T regulatory marker found: Folate Receptor 4
Kyoto, Japan - One of the exciting uses of stem cells is suppression of inflammatory reactions. In other words, various types of stem cells, such as mesenchymal stem cells, are known to possess membrane-bound molecules that inhibit T cell activation, or soluble products such as HLA-G5 which also inhibits T cell activation. The immune system can be regulated by...
HLG-G made by mesenchymal stem cells
Besancon, France - The ability of mesenchymal stem cells to inhibit inflammatory immune responses has been established in in vitro models, as well as in clinical trials of inflammatory conditions, such as the trials of Osiris for treatment of GVHD and Crohn's disease. In a recent paper (Selmani Z et al. HLA-G5 secretion by Human...
Stem cells for diabetes: 2 types better than one
Budapest, Hungary - Numerous studies have demonstrated that bone marrow stem cells, as well as other types of stem cells have the ability to reconstitute insulin production in animals whose insulin producing cells are damaged by chemical or immune agents. The problem with clinical translation of these types of approaches is the difficulty not just to obtain insulin production, but to obtain...
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