Category: Use (71)
Cord Blood Transplants Without Immune Suppression
Tempe, Arizona - The current use of cord blood as a substitute for bone marrow in individuals lacking an appropriate donor has made a tremendous impact on treatment of various hematological malignancies. Cord blood has several advantages to bone marrow, including reduced HLA matching requirements (4/6 is acceptable, wherease bone marrow has to be 6/6), widespread...
A new method of transfecting stem cells
Victoria, Australia - Anyone working with genetic modification of cells knows that transfection can be pretty difficult task depending on the cell population of study. Issues with transfection arise when cells are very fragile, or when the specific cell type for one reason or another does not allow efficient integration of the transgene. In a recent paper (Wagstaff et al...
MSC as Veto Cells II
Baltimore, MD - It is known that mesenchymal stem cells have veto-like properties. Essentially the veto cell inactivates, either through killing or induction of anergy, a cell that reacts against it. Theoretically, if the mesenchymal stem cells have veto-like properties, then this veto activity should be recognized in vivo by...
MSC = Veto cells
Duarte, CA - It is known that mesenchymal stem cells are potent immune modulators. The methods by which they inhibit various inflammatory reactions include production of immune suppressive cytokines such as IL-10, induction of tryptophan depletion using the enzyme IDO, and providing signal 1 in absense...
Stem Cell T Stimulation
Bethesda, Maryland - The return of ex vivo expanded T cells into an "empty compartment" has been used successfully by Steven Rosenberg and various researchers at the NIH for treatment of cancer. Essentially the idea is that when T cells are placed into a compartment that is lymphodepleted, then the T cells will proliferate by homeostatic expansion and be able to...
Limb Ischemia: Follow the leader
Nagoya, Japan - Readers of StemCellPatents.com will be familiar with a previous publication stating that cord blood derived stem cells can accelerate reconstitution of hematopoietic stem cells. This concept of one type of stem cell helping other types of stem cells was demonstrated in a recent paper by Kajiguchi et al (Safety and...
In vitro cord blood immune suppression
Chicago, IL - The ability to use allogeneic cord blood transplants, without immune suppression is under great discussion. On the one hand, it is a fact that administration of allogeneic cord blood does not elicit GVHD when administered to non-immune suppressed patients (type "Bhattacharya N" and "cord blood" in pubmed for example papers). On the other hand...
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Inflammation Puts Immune System in a TRANCE
Munster, Germany – The concept of immunological tolerance is paramount to stem cell therapeutic applications. Specifically, the ability to induce tolerance would allow for use of allogeneic stem cell therapeutics using "off-the shelf" cell lines that are well characterized and standardized for induction of specific biological activities. Tolerance induction is maintained by many...
Embryonic Stem Cells used to Treat 35 Patients
We at StemCellPatents.com have been most fascinated by the first clinical report of using embryonic stem cell-derived products .
In response to our coverage of this event, the senior author of the paper, Dr. H.L. Trivedi has requested us to post the following:
" Thank you for your interest in... Iowa City, Iowa USA
Due to the great interest generated by the first clinical use of embryonic stem cells we decided to see other papers in the area of immunological activities of embryonic stem cells.
The possibility that embryonic stem cells can be immune suppressive and therefore transplanted across... 7 Comments
Tolerogeneicity of Embryonic Stem Cells in Allogeneic animals
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