Category: Immunology (24)
Mesenchymal Stem Cells Inhibit Gamma Delta T Cell Proliferation
Toulouse, France -
We have previously discussed that mesenchymal stem cells inhibit T cell proliferation, activate suppressor T cells, inhibit homeostatic T cell expansion and can be used as universal donors in some situations due to their hypoimmunogenic activies as well...
Periodontal Ligament Mesenchymals are Immune Suppressive
Mesenchymal stem cells, or cells resembling these cells, have been found in a variety of different tissues in addition to the bone marrow. These include, fat, menstrual blood and teeth. One interesting question is how these cells differ from each other.
In a recent paper, (Wada et al... Paris, France - It is widely known that mesenchymal stem cells, whether derived from the bone marrow, cord blood, or menstrual blood all possess some degree of immune suppressive activity. This is one of the reasons why mesenchymal stem cells are being used in clinical trials in a... The stimulation of immunity against cancer has been demonstrated to some extent in conditions of hematopoietic malignancies. For example, CML patients who are recipients of allogeneic stem cell grafts, after relapse, can be induced into remission by administration of donor specific lymphocytes. Another method of stimulating immunity in... Ein Kerem, Israel - As you may have noticed, we at StemCellPatents.com seem to stay way from the whole politics of this "embryonic stem cell debate". The main reason being that there have been numerous advances made in the area of adult stem cells, already being in Phase III of clinical trials, while formal US clinical trials of embryonic stem cells have not even... Felix Platter -Spital, Switzerland - Immune regulatory effects of mesenchymal stem cells include suppression of allogeneic lymphocyte proliferation, stimulation of T regulatory cells, and secretion of soluble immune suppressive molecules such as soluble HLA-G. In a recent paper... Jerusalem, Israel - Stem cell therapy for conditions such as multiple sclerosis is promising in part because of the possibility of remyelination, as well as the immune modulatory properties of the stem cells, especially mesenchymal stem cells. While others have published that 
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Selecting Potent Immune Suppressive Mesenchymal Stem Cells
CTLA-4 Inhibition in Hematological Malignancies
ES cells as immune modulators: look out MSCs !!
Mesenchymal Stem Cells Inhibiting Homeostatic Proliferation
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Mesenchymal Stem Cells for Multiple Sclerosis
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T regulatory cells that inhibit multiple sclerosis that are not T reg
Cambridge, MA -
Multiple sclerosis is mediated by autoimmune T cell responses against components of the myelin basic sheath, for example myelin basic protein, myelin oligodendrocyte protein, and phospholipid protein. Stem cell therapy, especially with universal donor mesenchymal stem cells or endometrial regenerative cellsWednesday June 4th, 2008 @ 11:00:21 EST
Fetal cells home to injured mother tissue
The current accepted method of using cord blood is for post myeloablative hematopoietic reconstitution in patients with leukemias, or other hematological/metabolic disorders. Essentially the idea is that if you destroy the resident stem cells and administer "healthy" stem cells, then the progeny of the healthy stem cells will act in a dominant manner to reverse the disease. Many clinicians...
Ex vivo expanded Treg cells protection against allograft rejection
Chicago, IL, USA - Understanding methods of manipulating the immune system to accept allogeneic grafts without the continued need for immune suppression would not only solve the problem of organ transplant rejection but would also bring stem cell therapy (especially embryonic) closer to reality. One interesting method of bringing about such an "immunological...