Category: Neural (28)
Hair Stem Cells for Injured Nerves
Sagamihara, Japan -
Hair follicle stem cells have previously been demonstrated to possess various characteristics of other stem cells, including migration to SDF-1, thus potentially allowing intravenous injection. Also this stem cell population has been proposed, along with adipose stem cells, to have immune...
G-CSF Makes You Smarter
Münster, Germany -
G-CSF is widely used as a stem cell mobilizer, inducing complement-dependent exit of CD34 and mesenchymal stem cells from the bone marrow. It has been postulated that G-CSF has not just hematopoietic but also neurogenic activity. For example, a study reported that G-CSF administration... Göteborg, Sweden - Stem cells grown in culture are known to secrete a variety of factors, some of which have ability to protect tissue from apoptosis. For example, media from adipose stem cells cultured in hypoxia has been demonstrated to inhibit neonatal ischemic injury in a mouse model of cerebral palsy. Patent #
Neuroprotective Stem Cell Secreted Peptides
Autologous Adipose for Multiple Sclerosis
The use of autologous stem cell therapy has many theoretical and practical advantages. Autologous bone marrow mononuclear cells were originally used for treatment of ischemic heart failure, and subsequently to prevent post-infarct remodeling. Numerous other uses of autologous fat...
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Fat Stem Cells Against Brain Damage
Indianapolis, IN -
The ability of autologous adult stem cells to mediate neural protection subsequent to brain insults has been previously documented. For example, it is known that after a stroke, bone marrow stem cells mobilize, and patients with higher degree of mobilization actually have better post-stroke recovery. There are also reports of...
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Exercise Increases Neural Stem Cells
Taiwan - Neural stem cells are known to exist in post-natal animals. For example, during pregnancy, an increase in mitotic cells has been reported in the brains of the mother. This has been ascribed to numerous hormones and growth factors, including prolactin and human chorionic gonadotrophin.
Furuta et al. (Gestation-induced cell proliferation in the rat brain. Brain Res Dev...
Chronic Inflammation Inhibits Endogenous Neural Stem Cells
Valencia, Spain -
Mesenchymal stem cells are widely known to possess anti-inflammatory and immune modulatory activity. The regenerative and trophic functions of this type of stem cell may actually be less important than their ability to block pathological cytokine expression. In fact, the first non-hematopoietic...
Tooth in the Brain: Tooth Mesenchymal Stem Cells Made into Neurons
Kaohsiung, Taiwan -
The ability of mesenchymal stem cells to differentiate into neurons and neuron-like cells has been documented. For example, mesenchymal stem cells have been demonstrated to be beneficial in case reports of multiple sclerosis, as well as in early clinical trials. Usually mesenchymal stem cells are...
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Stem Cell Therapy of Multiple Sclerosis: Positive Case Reports
The use of stem cell therapy for multiple sclerosis has been previously reported in case reports, including from Dr. Simon Slavin's group in Israel.
In multiple sclerosis the rationale for why stem cell therapy would have beneficial effects derives from observations that some types of stem cells, such as
Immunology Instead of Stem Cells: Vaccine for Alzheimer's
Huntington Beach, CA -
A recent paper from Dr. Agadjanyan's group at the Institute of Molecular Medicine (Movsesyan et al. Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy. PLoS ONE 2008 May 7;3(5):e2124) reports the successful treatment of a mouse model of Alzheimer's using DNA vaccination...
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