Category: Migration (30)

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Hair stem cells migrate to SDF-1

Chicago IL-

An argument has been made that various current day therapeutic uses of stem cells that involve intravenous administration is that "you cant just inject stem cells intravenously and you will get tissue repair".  Obviously there are certain situations in which the tissue will not be repaired, however, this concept of intravenous stem cell administration is not...

Monday March 16th, 2009 @ 03:12:44 EST

Different mobilizers for different stem cells

London, UK -

While the human body does not have the regenerative capacity of a salamander, there are endogenous regenerative mechanisms that exist in the human.  For example, bone marrow progenitors are known to mobilize after situations of tissue injury, the idea being that they contribute to the healing process.  This is evident in stroke, where...

Making stem cells find apoptotic cells

Torino, Italy -

Hematopoietic stem cells and mesenchymal stem cells are known to more or less find their way to injured tissue.  This is one of the reasons why companies such as Osiris can get away with simply intravenously injecting their mesenchymal stem cells and still get potent...

Wednesday October 8th, 2008 @ 21:06:39 EST

Low Hematopoietic Stem Cells in Alzheimer's?

Tübingen, Germany -

The chemokine SDF-1 is known to attract hematopoietic stem cells and mesenchymal stem cells.  Under basal conditions it is produced by the bone marrow stromal cells, this is why hematopoietic stem cell transplants can be performed by intravenous administration and they find their way back to...

Friday September 12th, 2008 @ 23:29:24 EST

TLRs and Stem Cell Mobilization

Cornell University, New York City, New York -

We have discussed on how various inflammatory stimuli may one the one hand act as stem cell chemo-attractants, and on the other hand may actually cause mobilization of stem cells to leave the bone marrow.  For example, injured tissue is associated with platelet activation, causing release of agents such as Friday August 22nd, 2008 @ 19:51:42 EST

Stroke without thrombolytics calls stem cells

Regensburg, Germany -

Bone marrow stem cells are known to possess numerous regenerative properties in humans (clinical trials), including healing of heart attack damaged myocardium, reversing liver failure, and stimulating new blood vessel production in patients with ischemic limbs.  Bone marrow...

Monday June 16th, 2008 @ 02:33:35 EST

Notch Ligand Inhibits Angiogenesis

Oxford, UK -

The notch signalling pathway has been widely studied in development and tissue specification.  Notch acts as a receptor for various ligands and upon binding translocates into the nucleus to induce expression of various genes.  Two ligands of notch, Delta and Serrate have been implicated in the inhibition of stem cell...

Temporary Hypoxia is Good for Mesenchymal Stem Cells

St Louis, MO -

Mesenchymal stem cells are very exciting since they can be used in an allogeneic manner.  While these cells have demonstrated therapeutic effects in liver failure, heart failure, and even diabetes, the main question still remains, how to increase...

Tuesday June 3rd, 2008 @ 10:28:52 EST

Viral Inflammation Mobilizes Stem Cells

Shanghai, China - It is known that various stem cell types, including mesenchymal and hematopoietic have the ability to home to injured tissue. Mechanisms of homing usually are associated with agents such as stromal...

Acidic mesenchymal stem cells

Los Angeles, CA - Tissue injury is known to cause mobilization of various types of stem cells. For example, after patients have a heart attack, CD34 stem cells, and other types of stem cells are known to mobilize from the bone marrow and enter systemic circulation. Mobilization involves Saturday February 16th, 2008 @ 19:51:40 EST

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