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Leptin Blocks T Regulatory Cell Expansion

[Watch the Video]This video describes a publication teaching the use of antileptin antibody to augment proliferation of T regulatory cells.  The T regulatory cells is a specific component of the immune system that is activated by mesenchymal stem cells and has been associated with suppression of autoimmunity.  Essentially the video provides a neat...
Sunday August 23rd, 2009 @ 04:23:26 EST

Mechanism of Multiple Sclerosis Stem Cell Therapy

[Watch the Video]Cleveland, Ohio -A recent study (Bai et al. Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia. 2009 Aug 15;57(11):1192-203) asked the question of whether human mesenchymal stem cells may be useful in the treatment of the mouse model of multiple sclerosis, experimental...
Friday July 24th, 2009 @ 13:04:52 EST 2 Comments

Lithium for Treatment of Multiple Sclerosis

[Watch the Video]This video describes a publication which used the experimental allergic encephalomyelitis model of multiple sclerosis to test immunological effects of lithium.  The authors demonstrated profound inhibition of disease, as well as stimulation of antiinflammatory cytokines.  It seemed like the anti-inflammatory effects of lithium were associated with the inhibition of...
Wednesday July 15th, 2009 @ 04:43:05 EST

Treatment of Degenerative Disc Disease by Bone Marrow Stem Cells

Degenerative disc disease is a major problem, causing billions of dollars in lost work and medication.  Patents such as # 6,723,335 cover the use of stem cell injection into the nucleus pulposus of the disc in order to stimulate regeneration.  In a recent paper (Yang et al. Mesenchymal Stem Cells Arrest Intervertebral Disc Degeneration Through Chondrocytic...
Thursday July 9th, 2009 @ 20:13:43 EST 2 Comments

Apoptotic Cells Secrete Angiogenic Factors

It is a medical mystery why approaches such as extracorporeal ozone therapy or even photopheresis seem to have therapeutic effects in certain situations.  One possibility is that stressing of cells outside of the body causes formation of apoptotic bodies, with the apoptotic bodies having a therapeutic effect.The possibility of apoptotic bodies mediating...
Saturday June 27th, 2009 @ 03:54:59 EST

Hair Stem Cells for Injured Nerves

Sagamihara, Japan -Hair follicle stem cells have previously been demonstrated to possess various characteristics of other stem cells, including migration to SDF-1, thus potentially allowing intravenous injection.  Also this stem cell population has been proposed, along with adipose stem cells, to have immune modulatory...
Wednesday June 10th, 2009 @ 11:06:44 EST

Pulmonary Fibrosis Treated by Mesenchymal Stem Cells

Melbourne, Australia -Systemic administration of stem cells is usually associated with preferential localization into the lung and liver.  Lung conditions such as acute respiratory distress syndrome have no cure with exception of transplantation, which is limited to a small number of patients.  The rationale of using mesenchymal stem cells for pulmonary diseases comes from their...
Monday June 8th, 2009 @ 13:44:53 EST 1 Comment

Free bone allograft prevents acute immune reaction

London, Canada -Antibody-mediated acute vascular rejection (AVR) is a major problem in organ transplantation.  The C3H to BALB/c heterotopic (second heart) cardiac transplant model resembles the human condition of AVR.  When recipients are given a course of the conventionally used immune suppressant agent cyclosporin A, grafts survive 15 days.  This is approximately 8 days more than...
Tuesday May 26th, 2009 @ 22:40:47 EST 1 Comment

G-CSF Makes You Smarter

Münster, Germany -G-CSF is widely used as a stem cell mobilizer, inducing complement-dependent exit of CD34 and mesenchymal stem cells from the bone marrow.  It has been postulated that G-CSF has not just hematopoietic but also neurogenic activity.  For example, a study reported that G-CSF administration accelerates post...
Saturday May 16th, 2009 @ 00:59:17 EST

Mouse Liver Failure Treated by Human Cord Blood Stem Cells

Sacramento, CA -It is known that administration of autologous bone marrow cells into patients with liver failure induces clinical improvement, at least in pilot trials of cirrhotic patients.  Mechanistically this may work through the process of transdifferentiation, that is, bone marrow directly differentiating to hepatocytes.  Or...
Friday May 15th, 2009 @ 04:07:34 EST 1 Comment

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