News Posts
Bergamo, Italy -
Although numerous studies, both preclinical and clinical have demonstrated the potency of adult stem cells for treatment of heart and liver degenerative conditions, relatively little work has been performed using stem cells for renal failure. In a recent paper (Imberti et al. Insulin-Like Growth Factor-1 Sustains Stem Cell Mediated Renal Repair. J Am Soc Nephrol. 2007 Oct...
Tuesday October 23rd, 2007 @ 22:45:44 EST
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Monday October 22nd, 2007 @ 00:49:12 EST
Minneapolis, MN -
MyoD is a basic helix-loop-helix myogenic transcription factor involved in differentiation of muscle cells.
In a recent paper (Asakura et al. Increased survival of muscle stem cells lacking the MyoD gene after transplantation into regenerating skeletal muscle.Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16552-7) scientists wanted to determine whether muscle stem cells...
Friday October 19th, 2007 @ 04:06:25 EST
Detroit, Michigan -
The ex vivo expansion of hematopoietic stem cells in large numbers would allow for numerous autologous transplant approaches to become a clinical reality. For example, one could hypothetically expand and keep frozen their own stem cells for when they need them later in life. Unfortunately, many attempts at expanding CD34 hematopoietic stem cells have failed to either...
Friday October 19th, 2007 @ 03:56:03 EST
New Orleans, LA -
The use of
adult stem cells for heart failure has previously been reported. What is interesting is the possibility of using autologous adult adipose derived stem cells for this condition. The beauty of adipose derived stem cells is, of course, that they are available in autologous settings in large numbers...
Wednesday October 17th, 2007 @ 10:15:41 EST
Paris, France -
It has previously been reported that
immunoglobulins play a fundamental role in stem cell mobilization. It is also known that intravenous immunoglobulin (IVIG) possesses numerous anti-inflammatory properties. In a recent paper (Ephrem et al. Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a...
Tuesday October 16th, 2007 @ 14:51:27 EST
Kyoto, Japan -
One of the exciting uses of stem cells is suppression of inflammatory reactions. In other words, various types of stem cells, such as mesenchymal stem cells, are known to possess membrane-bound molecules that inhibit T cell activation, or soluble products such as HLA-G5 which also inhibits T cell activation. The immune system can be regulated by stem cells through another means...
Tuesday October 16th, 2007 @ 14:38:43 EST
Besancon, France -
The ability of mesenchymal stem cells to inhibit inflammatory immune responses has been established in in vitro models, as well as in clinical trials of inflammatory conditions, such as the trials of Osiris for treatment of GVHD and Crohn's disease.
In a recent paper (Selmani Z et al. HLA-G5 secretion by Human Mesenchymal Stem Cells Is Required to Suppress T-lymphocyte and...
Monday October 15th, 2007 @ 19:46:23 EST
Budapest, Hungary -
Numerous studies have demonstrated that bone marrow stem cells, as well as other types of stem cells have the ability to reconstitute insulin production in animals whose insulin producing cells are damaged by chemical or immune agents. The problem with clinical translation of these types of approaches is the difficulty not just to obtain insulin production, but to obtain...
Sunday October 14th, 2007 @ 15:37:34 EST
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Research Triangle Park, NC -
We at stemcellpatents.com usually stick to scientific and sometimes patent law issues when we write this news section. However, a recent publication (Resnik. Embryonic Stem Cell Patents and Human Dignity. Health Care Anal. 2007 Sep;15(3):211-222. Epub 2007 Mar 29) on stem cell ethics made us discuss a topic that we usually don't touch upon: Ethics of...
Tuesday October 9th, 2007 @ 20:30:03 EST