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Neuroprotective Stem Cell Secreted Peptides

Göteborg, Sweden -Stem cells grown in culture are known to secrete a variety of factors, some of which have ability to protect tissue from apoptosis.  For example, media from adipose stem cells cultured in hypoxia has been demonstrated to inhibit neonatal ischemic injury in a mouse model of cerebral palsy.  Patent #Monday May 11th, 2009 @ 15:25:20 EST

Allogeneic rejection of embryonic stem cells

Nara, Japan -Seeing stem cell therapy as sources of cytokines or angiogenic factors allows the possibility that the stem cell will eventually be rejected but the therapeutic effect will remain.  For example, mesenchymal stem cells are known to secrete various immune modulatory factors, such as soluble HLA-G, which allows them to suppress inflammation.  If...
Monday May 4th, 2009 @ 02:15:43 EST

Medistem Fat Stem Cells Help Multiple Sclerosis Patients

San Diego, CA -[Watch the Video]Above is a video describing a recent publication, (Riordan et al, Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis Journal of Translational Medicine 2009, 7:29Monday April 27th, 2009 @ 19:07:38 EST

Low Oxygen Tension for Cancer Stem Cells: Keeping it Real

Tampa, FL -We have previously discussed the importance of mimicking the physiological environment when studying different types of stem cells, so why would this not be true also for tumor stem cells?  Specifically, it is known that hematopoietic stem cells reside in the hypoxic niche of the bone marrow.  This can also be said of neural progenitors.  Both of these types of...
Monday April 20th, 2009 @ 14:53:49 EST

Stem cells improve post-infarct heart function

Chicago, IL -The use of bone marrow stem cells post infarct has been reported to induce improvements in various cardiac parameters post-infarct.  In fact, even administration of stem cells in patients after chronic cardiac deterioration has been reported to have beneficial effects, although these are much more rare.Singh et al (Stem...
Tuesday April 14th, 2009 @ 02:43:11 EST 1 Comment

Novocell Awarded Seminal Stem Cell Patent

San Diego, CA (March 31, 2009) – Novocell, Inc., a stem cell engineering company, today announced that it has received U.S. Patent 7,510,876 with claims covering human definitive endoderm cells, an essential cell for generating not only pancreatic type cells, which Novocell is developing for use as a cell therapy for diabetes, but also other endoderm lineage-derived tissues and organs such...
Monday April 6th, 2009 @ 18:37:51 EST

CD34 to iPS: A New Look at Banking?

Boston, MA -The generation of inducible pluripotent stem cells (iPS) has allowed creation of embryonic-like cells that appear to have similar degree of pluripotency and gene expression.  Originally iPS cells were made from skin cells.  A more recent paper (Loh et al. Generation of induced pluripotent stem cells from human blood. Blood 2009 Mar 18) described...
Monday March 30th, 2009 @ 05:11:20 EST

Hair stem cells migrate to SDF-1

Chicago IL-An argument has been made that various current day therapeutic uses of stem cells that involve intravenous administration is that "you cant just inject stem cells intravenously and you will get tissue repair".  Obviously there are certain situations in which the tissue will not be repaired, however, this concept of intravenous stem cell administration is not as...
Monday March 16th, 2009 @ 03:12:44 EST

Rheumatoid Arthritis Model Treated by Mesenchymal Stem Cells

[Watch the Video]Mesenchymal stem cells are of great interest due to their ability to be injected intravenously and home to the area of injury, as well as the fact that they do not require matching with the recipient.  To date, mesenchymal stem cells have been used in the treatment of spinal cord...

Radiation Induced Bacterial Translocation Causes GVHD

[Watch the Video]When cord blood stem cells are used in the context of treatment of leukemia, graft versus host has been reported to occur in some patients.  Although incidence is reduced in patients who receive hematopoietic stem cells in the form of cord blood as compared to bone marrow, GVHD is still a concern.  An important question is why this does not seem to occur in...
Tuesday March 10th, 2009 @ 02:44:56 EST 1 Comment

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