News Posts
Multiple Sclerosis T Cell Receptor Diversity
At StemCellPatents.com we have discussed both in vitro and in vivo evidence for stem cells being able to play a therapeutic effect on multiple sclerosis. The main mechanism by which this occurs is through the ability of stem cells to generate new myelin, and in some cases actually regenerate neurons. However, in multiple sclerosis the main cause of the disease is...
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Mesenchymal Stem Cells Augmented by Estrogen
Indianapolis, Indiana -
Mesenchymal stem cells, have very potent therapeutic potential because they can be used in an allogeneic manner, they can differentiate into many new types of tissue, and they produce numerous growth factors. Mesenchymal stem cells have been demonstrated in non-clinical systems to be effect in
Duchenne Muscular Dystrophy Calls Stem Cells
Milan, Italy -
Duchenne Muscular Dystrophy is a lethal genetic condition, characterized by progressive muscle weakness caused by mutations in the dystrophin gene. Approaches to treatment of this condition have included the use of cord blood stem cells, however little functional improvement is seen, even in animal models. US patent 2 Comments
Mesenchymal Stem Cells Reverse Diabetes in C57 Strep Model
Santiago, Chile -
A recent paper (Ezquer et al. Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice. Biol Blood Marrow Transplant 008 Jun;14(6):631-40) described the therapeutic impact of bone marrow derived mesenchymal stem cells administered to mice with experimental...
Stem Cells and Liver Failure
Shanghai, China -
Liver failure is a major cause of moribidity and mortality, cited by some as the 7-10th largest cause of death. The possibility of stem cell therapy for liver failure is particularly attractive since intravenous administration of cells usually results in deposition into the liver.
Animal studies have demonstrated that endogenous
Mesenchymal stem cells made into nucleus pulposus cells
Lumbar disc degeneration is a significant cause of morbidity. Given that the key cells maintaining the mass of the disc are nucleus pulposus cells, one of the aims in regenerative medicine has been to treat disc degeneration by administration of stem cells.
However, one major question arises, would it be more beneficial to administer stem...
Immunology Instead of Stem Cells: Vaccine for Alzheimer's
Huntington Beach, CA -
A recent paper from Dr. Agadjanyan's group at the Institute of Molecular Medicine (Movsesyan et al. Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy. PLoS ONE 2008 May 7;3(5):e2124) reports the successful treatment of a mouse model of Alzheimer's using DNA vaccination...
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Interview with Novocell CEO Alan Lewis
In this StemCellPatents.com interview, our special guest interviewer, Thomas Ichim, CEO of Medistem, speaks with Alan Lewis, CEO of Novocell, regarding the company's advances towards curing diabetes. This interview examines many aspects of Novocell which...
FGF-1 Gene Therapy Double Blind Trial
Münster, Germany -
Understanding and manipulating the formation of new blood vessels, a process called angiogenesis, has been one of the highly sought-after goals of the biotechnology industry. One the one hand, inhibition of angiogenesis is desirable in cancer, since tumors need new blood vessels to stay alive. On the other hand, angiogenesis stimulation could...
Parathyroid hormone mobilization and limb ischemia
Naples, Italy -
The administration of bone marrow stem cells into ischemic muscles for treatment of critical limb ischemia is currently being performed in clinical trials, with results demonstrating stimulation of angiogenesis and functional improvement. Given that a substantial amount of the angiogenic response seems to...