News Posts
CAR cells drive hematopoiesis
Kyoto, Japan - It is an established fact that administration of bone marrow hematopoietic cells systemically leads to their homing to the recipient bone marrow due in part to constitutive secretion of the cytokine SDF-1, otherwise known as CXCL12, by the bone marrow stroma. It is also known that tissue injury, whether by a pathological event such as a heart attack, or stroke, also results...Tuesday December 19th, 2006 @ 22:57:43 EST
Clearing the genetic slate for curing diabetes
Braunschweig, Germany – It is known that a wide variety of agents that are involved epigenetic manipulation of cells are potential candidates for use in “transdifferentiation” or alteration of cellular phenotype. Histone deacetylases are critically involved in maintaining chromatin packing, and thereby transcriptionally silencing various parts of the genome. It is known that...Tuesday December 19th, 2006 @ 18:56:10 EST
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Cord Blood Differentiation to Muscle
The possibility of stem cell treatment for muscular degenerative diseases has prompted numerous investigations. Duchenne muscular dystrophy is a dehabilitating disorder that afflicts approximately 1 in 35,000 boys. This disease is caused by a mutation in the dystrophin gene, whose protein product is found at high amounts in the cardiac and skeletal muscles and plays a role in sarcolemmal...Friday December 15th, 2006 @ 23:33:14 EST
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In vitro cord blood immune suppression
Chicago, IL - The ability to use allogeneic cord blood transplants, without immune suppression is under great discussion. On the one hand, it is a fact that administration of allogeneic cord blood does not elicit GVHD when administered to non-immune suppressed patients (type "Bhattacharya N" and "cord blood" in pubmed for example papers). On the other hand, some believe that the allogeneic...Wednesday December 13th, 2006 @ 09:10:30 EST
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Inflammation Puts Immune System in a TRANCE
Munster, Germany – The concept of immunological tolerance is paramount to stem cell therapeutic applications. Specifically, the ability to induce tolerance would allow for use of allogeneic stem cell therapeutics using "off-the shelf" cell lines that are well characterized and standardized for induction of specific biological activities. Tolerance induction is maintained by many...Tuesday December 12th, 2006 @ 22:16:18 EST
Curing Cancer By Differentiation
Milan, Italy - It is believed that out of a 1000 cancer cells, less than 1, or maybe even less than that are actual "tumor stem cells", and that this population is responsible for dividing and maintaining the tumor mass. The question has been, how to target this very small population. A recent paper (Piccirillo et al. Bone morphogenetic proteins inhibit the tumorigenic potential of human...Monday December 11th, 2006 @ 20:57:56 EST
Embryonic Stem Cells used to Treat 35 Patients
We at StemCellPatents.com have been most fascinated by the first clinical report of using embryonic stem cell-derived products . In response to our coverage of this event, the senior author of the paper, Dr. H.L. Trivedi has requested us to post the following: " Thank you for your interest in our work. I would like to draw the...Saturday December 9th, 2006 @ 18:10:39 EST
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Artificial Cartilage Implant
Boston, MA- Artificial joints and components generated in vitro for surgical implantation in patients with injured joints is an area of intense research and commercialization interest. Hydrogels are generally defined as a network of polymer chains that are water-soluble and can be used for implantation of drugs or cells into a desired anatomical area. In a recent paper (Hannouche D et al...Saturday December 9th, 2006 @ 15:05:11 EST
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Liver Changing to Islets
Sao Paulo, Brazil - It is known that oval cells of the liver, which act as stem cells, can differentiate into hepatocytes and bile duct epithelium. Oval cells expand when hepatocyte damage occurs and hepatocye mitogenesis is concurrently inhibited. Previously it was published that these oval cells, which ironically also express hematopoietic stem cell markers such as CD34, CD90 and stem...Saturday December 9th, 2006 @ 14:48:07 EST
Turning it up a Notch
Notch is a very interesting molecule. It acts as a receptor (for ligands such as Serrate), as well as a transcription factor when activated. The role of Notch in assigning tissue fate is established across the animal kingdom. A patent at StemCellPatents.com # 7,138,276, entitled Differentiation-suppressive polypeptide serrate-2...Friday December 8th, 2006 @ 02:37:06 EST
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