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Endothelial Stimulation of Hematopoietic Engraftment

Durham, North Carolina Chute et al reported today that administration of mouse endothelial cells to irradiated B6 recipients was capable of accelerating hematopoietic reconstitution after sublethal and lethal irradiation. In a paper entitled "Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice" published in today's...
Friday November 10th, 2006 @ 12:51:30 EST

Synchronization of Differentiation is Key

LONDON UK Researchers in the UK have published in today's online version of the journal Nature (Maclaren et al. Retinal repair by transplantation of photoreceptor precursors, Nature. 2006 Nov 8.) an important finding in regards to stem cell therapy of photoreceptor loss It was known in the art that transplantation of a wide variety of stem cells into injured retina is usually not capable...
Wednesday November 8th, 2006 @ 14:50:25 EST

Stem Cells Follow The Leader

Singapore- Scientists at Viacell announced the ability of unrestricted somatic stem cells (USSC) to enhance migration and repopulation of hematopoietic stem cells in an animal model through secretion of the stem cell chemotactic factor SDF-1. Chan et al in a publication titled "ENHANCED IN VIVO HOMING OF UNCULTURED AND SELECTIVELY AMPLIFIED CORD BLOOD CD34+ CELLS BY CO-TRANSPLANTATION WITH...
Thursday October 26th, 2006 @ 11:46:17 EST

Modulation of Histone Deacetylases For Generating Heart Tissue

London, Canada Researchers at the University of Western Ontario have published a paper in the October 15th, 2006, issue of the Journal of Cell Sciences (Karamboulas C et al, HDAC activity regulates entry of mesoderm cells into the cardiac muscle lineage. J Cell Sci. 2006 Oct 15;119(Pt 20):4305-14) describing mechanisms by which inhibition of histone deacetylases induces differentiation of...
Sunday October 15th, 2006 @ 23:14:43 EST

Clinical Trial of “Retro-Differentiated” Stem Cells: A Novel Way to Generate Autologous Stem Cells

London UK One of the major limitations of stem cell transplantation is the need to overcoming allogeneic barriers. The generation of stem cells from already differentiated tissue would significantly revolutionize the area of stem cell therapeutics. In a paper published today (Abuljadayel et al. Infusion of autologous retrodifferentiated stem cells into patients with beta-thalassemia...
Monday October 9th, 2006 @ 19:34:50 EST

Clinical Trial Demonstrating Benefit of Bone Marrow Stem Cells Administered > 3 Months Post Infarction

Frankfurt, Germany The concept of utilizing bone marrow cells to decrease scar tissue and improve patient prognosis after myocardial infarction has been previously tested clinically in patients. The majority of previous trials involved administration of autologous bone marrow within a certain time frame (usually 2-12 days) after the myocardial infarct. The reason for this is that subsequent...
Thursday September 21st, 2006 @ 19:29:47 EST

Ability of ES Cells to De-differentiated and Reprogram Other Cells is Augmented by Nanog Overexpression in ES Cells

Edinburgh, UK - Dr. Austin Smith’s group reported the ability of embryonic stem cells to reprogram somatic cells is markedly augmented by overexpression of the Nanog transcription factor in the embryonic stem cell (Silva J et al. Nanog promotes transfer of pluripotency after cell fusion. Nature. 2006 Jun 22;441(7096):997-1001). These findings are of great importance to the area of...
Friday July 21st, 2006 @ 19:27:55 EST

Allogeneic Stem Cell Angiogenic Therapy in Absence of Immune Suppression

Seoul, Korea Ischemia of the extremities, either of atherosclerotic or nonatherosclerotic origin is a major cause of amputations. In a study published today (*Kim SW et al. Successful stem cell therapy using umbilical cord blood-derived multipotent stem cells for Buerger's disease and ischemic limb disease animal model. Stem Cells. 2006 Jun;24(6):1620-6*), successful treatment of Buerger’s...
Saturday June 24th, 2006 @ 12:27:58 EST

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