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Preventing Diabetes Associated Cardiac Dysfunction by MSC

Cairo, Egypt -Bone marrow stem cell therapy is being clinically used by various institutions for treatment of non-hematopoietic diseases.  For example, it has been previously reported in clinical trials that administration of bone marrow cells prevents pathological cardiac remodeling post-infarct.  Additionally, bone...
Sunday January 18th, 2009 @ 00:00:57 EST 2 Comments

Selecting Potent Immune Suppressive Mesenchymal Stem Cells

Paris, France -It is widely known that mesenchymal stem cells, whether derived from the bone marrow, cord blood, or menstrual blood all possess some degree of immune suppressive activity.  This is one of the reasons why mesenchymal stem cells are being used in clinical trials in a "universal...
Saturday January 17th, 2009 @ 03:17:00 EST

Different mobilizers for different stem cells

London, UK -While the human body does not have the regenerative capacity of a salamander, there are endogenous regenerative mechanisms that exist in the human.  For example, bone marrow progenitors are known to mobilize after situations of tissue injury, the idea being that they contribute to the healing process.  This is evident in stroke, where bone marrow...
Sunday January 11th, 2009 @ 14:59:04 EST

Neostem's VSEL Cells Have Biological Significance

Katowice, Poland -Biological significance is a very important factor to look at when evaluating various stem cell technologies or types of stem cells.  While companies usually like to believe that their stem cells are "the best", it is often important to ask the question whether the stem cells play a natural role in the body, and if therapeutically that role can be...
Sunday January 4th, 2009 @ 22:14:56 EST

Medistem Files IND for Endometrial Regenerative Cells

San Diego, CA -Medistem Inc has announced in the press release below that it has filed an Investigational New Drug (IND) application with the FDA for use of its Endometrial Regenerative Cells (ERC) for the treatment of critical limb ischemia.  The Principle Investigator for the proposed study Dr. Michael Murphy from Indiana University has previously Sunday December 28th, 2008 @ 16:32:06 EST

Bone Marrow Stem Cells for Renal Failure

São Paulo, Brazil -Bone marrow is classically known to be the site of hematopoiesis, thus "bone marrow transplant" has been successfully used for decades as a means of treating various hematological malignancies in which the recipient hematopoietic compartment is replaced by donor-derived stem cells.  More recent investigations have demonstrated that Monday December 22nd, 2008 @ 18:13:58 EST 6 Comments

Cardiac Stem Cell Therapy in 2 Year Old

Giessen, Germany -Adult stem cell therapy has previously been used for heart failure, primarily in acute post-infarct situations.  In a very interesting paper (Rupp et al. Intracoronary administration of autologous bone marrow-derived progenitor cells in a critically ill two-yr-old child with dilated cardiomyopathy. Pediatr Transplant 2008 Nov 26) autologous bone marrow was...
Monday December 15th, 2008 @ 22:09:43 EST

Possible Prostate Cancer Stem Cell

Buffalo, New York -The tumor stem cell concept implies a small self-renewing population of cells in a tumor mass is responsible for maintaining the bulk of the tumor which comprises primarily of differentiated cells.  This was demonstrated by O'Brien et al in the case of colon cancer in which only the small, quiescent, CD133 cells from the tumor were capable of causing tumor growth in...
Sunday December 7th, 2008 @ 16:13:57 EST

Stressed Mesenchymals Make More IGF-1

New Orleans, Louisiana -We at have been stating for a while now that one of the future areas of our field will be not simply determining if stem cell therapies work, but how to optimize them.  For example, bone marrow derived MSC are already in Phase III clinical trials, and numerous other cell based therapies are working their way through...
Sunday November 30th, 2008 @ 20:53:23 EST

Fat Stem Cells Against Brain Damage

Indianapolis, IN -The ability of autologous adult stem cells to mediate neural protection subsequent to brain insults has been previously documented.  For example, it is known that after a stroke, bone marrow stem cells mobilize, and patients with higher degree of mobilization actually have better post-stroke recovery.  There are also reports of Sunday November 23rd, 2008 @ 15:19:51 EST 1 Comment

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