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Caloric Restriction Stimulates Angiogenesis Through Adiponectin

Nagoya, Japan -Caloric restriction is by far the most documented method of extending lifespan.  People have filed patents on methods of identifying compounds that induce biological effects similar to caloric restriction.  There are several theories as to how caloric restriction mediates its effects.  One interesting one is that it modulates the Sunday November 16th, 2008 @ 12:57:10 EST

Mesenchymal Stem Cells Treating Pig Diabetes

Wuhan, China -Mesenchymal stem cells are most likely to be the first clinically approved stem cell type in the United States for non-hematopoietic conditions, with several clinical trials in mid to late Phase III.  Mesenchymal stem cells are attractive because they can be used in a "universal donor" fashion, in part due to their immune modulatory...
Tuesday November 4th, 2008 @ 12:39:02 EST 1 Comment

Angiogenesis requires endogenous stem cells

Nagoya, Japan -Implantation of various stem cell populations into an ischemic muscle has been demonstrated to induce neovascularization both in animal studies, and in clinical trials.  Some people believe that the therapeutic angiogenesis may be occuring by differentiation of the stem cells injected into new endothelial cells, others...
Monday November 3rd, 2008 @ 21:47:44 EST

CTLA-4 Inhibition in Hematological Malignancies

The stimulation of immunity against cancer has been demonstrated to some extent in conditions of hematopoietic malignancies.  For example, CML patients who are recipients of allogeneic stem cell grafts, after relapse, can be induced into remission by administration of donor specific lymphocytes.  Another method of stimulating immunity in...
Monday November 3rd, 2008 @ 03:13:04 EST

Potentiating Mesenchymal Stem Cells for Cardiac Regeneration

Cincinnati, Ohio -Mesenchymal stem cells are attractive for therapeutics development because they can theoretically be used as a "one size fits all".  Additionally, their ability to home to area of tissue injury, in part by CXCR4 expression allows for intravenous...
Sunday October 26th, 2008 @ 12:13:01 EST 1 Comment

Sensitizing CML Precursors to GVL

Bethesda, Maryland -Chronic myeloid leukemia (CML) is a cancer of the myeloid committed stem cell, which is caused primarily by the oncogenic chimeric protein BCR-ABL.  Immune responses are known to control progression of CML.  For example, patients with CML taking interferon that have higher NK cell activity live longer.  There are many proteins...
Sunday October 19th, 2008 @ 12:42:24 EST

Making stem cells find apoptotic cells

Torino, Italy -Hematopoietic stem cells and mesenchymal stem cells are known to more or less find their way to injured tissue.  This is one of the reasons why companies such as Osiris can get away with simply intravenously injecting their mesenchymal stem cells and still get potent...
Wednesday October 8th, 2008 @ 21:06:39 EST

ES cells as immune modulators: look out MSCs !!

Ein Kerem, Israel -As you may have noticed, we at seem to stay way from the whole politics of this "embryonic stem cell debate".  The main reason being that there have been numerous advances made in the area of adult stem cells, already being in Phase III of clinical trials, while formal US clinical trials of embryonic stem cells have not even been...
Sunday October 5th, 2008 @ 21:20:25 EST

Cancer Vaccine Against Aurora Kinase

Ehime, Japan -Cancer vaccines are attractive because of their general lack of toxicity, their ability to selectively destroy malignant tissue, as well as possibility of preventing micrometastasis.  Immunotherapy of cancer has been attempted for more than a century, however conflicting results and lack of clear-cut benefit in Phase III trials has...
Thursday October 2nd, 2008 @ 10:51:49 EST

Selecting for better mesenchymal stem cells

New Orleans, LA - Mesenchymal stem cells have made significant therapeutic advances with positive clinical results in heart disease, Crohn's, and GVHD.  The question is, "how to improve efficacy?"Mesenchymal stem cell powerhouse Dr. Darwin Prockup published a recent paper (Lee et al. The CD34-like protein PODXL and...
Saturday September 27th, 2008 @ 21:46:45 EST

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