News Posts
Autologous G-CSF mobilized CD34 for angina
Chicago, IL - The use of stem cells for myocardial repair was originally proposed after mouse studies demonstrated what appeared to be human bone marrow derived stem cells differentiating into myocardium. Subsequently, these experiments were translated into clinical studies, which utilized autologous bone marrow cells as sources...
Mobilized Stem Cells for Peripheral Artery Disease
Hangzhou, China -
The use of autologous bone marrow stem cells for peripheral artery disease is occuring in the US as part of clinical trials. The rational is that insertion of stem cells into ischemic muscle leads to angiogenesis either through the endothelial precursor... Rochester, NY -
The understanding how to modulate the balance between generation of new functional tissue and creation of a fibrotic scar would allow for the treatment of numerous conditions associated with scar tissue deposition.
It is known that stem cells can help to heal scarred tissue ranging from myocardium, to
PPAR gamma agonists: inhibition of fibrosis
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IL-10 in healing of nerves
Sheffield, UK - There seems to be some connections between the immune system and various stem cell niches. For example, while the role of the stromal cells is to provide nutrients for the bone marrow hematopoietic stem cells, these cells also play anti-inflammatory functions. In some situations activations of enzymes associated...
Cardiac Stem Cell Migration Dependent on p38
Wuhan, China -
Many tissues have tissue resident stem cells. Although not in high numbers, these stem cells have nevertheless been demonstrated to play at least some role in regeneration after injury. Stem cells in tissues can be isolated by their side population characteristics, or by their expression of
Embryonic stem cells into urinary epithelium
Asahi, Japan - Generation of three dimensional structures that can be implanted into patients is one of the exciting prospects offered by stem cell technologies. For example, three dimensional structures such as heart valves and "uteri"http://www.stemcellpatents.com/patents-show-51 have already been engineered in vitro. One...
GM-CSF protecting diabetes
Sherbrooke, Quebec - The immune suppressive activity of mesenchymal and hematopoietic stem cells is well known. An interesting question however is whether activation/mobilization of these cells with pharmacological agents can be used to induce systemic immune modulation...
Infectious Antigen Specific Tolerance by Dendritic Cells
Wuhan, China - The possibility of T regulatory cells inducing tolerance, both antigen specifically, and antigen-nonspecifically through the modulation of antigen presenting cell function has been previously established. What is more interesting is the concept of an antigen presenting cell being able to transfer tolerance without the...
Molecular Mechanisms of Retina Regeneration in Chickens
Oxford, OH - Degeneration of the retina is a significant problem associated with several diseases that cause blindness, such as macular degeneration. In a recent paper (Haynes et al. BMP signaling mediates stem/progenitor cell-induced retina regeneration. Proc Natl Acad Sci U S A. 2007 Dec 14) the investigation of molecular signals associated wtih regeneration of...
Tooth stem cells for heart attack
Valencia, Spain - Mesenchymal stem cells have been detected in bone marrow, peripheral blood, muscle and even in menstrual blood. Another...