Chiba, Japan -
The clinical use of G-CSF (Neupogen) has allowed for mobilization of stem cells in the peripheral blood stem cell transplant setting, as well as a means of accelerating hematopoietic recovery in a variety of settings.
A recent paper suggests that mobilization of stem cells using G-CSF may be useful not only for hematopoietic indications but also for inducing repair post spinal cord injury. Koda et al (Granulocyte colony-stimulating factor (G-CSF) mobilizes bone marrow-derived cells into injured spinal cord and promotes functional recovery after compression-induced spinal cord injury in mice Brain Res. 2007 Mar 1) used a GFP-bone marrow transplanted system in which spinal cord injury was induced by a static load (20 g, 5 min) at the T8 level. Subsequent to injury, G-CSF was administered at 200 micrograms per kilogram per day for 5 days.
Mice that had recieved G-CSF had a higher number of cells in the white matter and superior hindlimb locomotor function as compared to control mice.
Since it is known that other therapies may mobilize stem cells, such as hyperbaric oxygen (Thom et al. Stem cell mobilization by hyperbaric oxygen. Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1378-86), it will be of interest to compare these to G-CSF in the area of spinal cord injury repair.