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Bone marrow stem cells in pulmonary hypertension

Tuesday November 27th, 2007 @ 03:13:15 EST

From Category: Use

New Orleans, Louisiana -

Adult stem cells have been used clinically in treatment of heart failure, liver failure, and advanced peripheral artery disease. One exciting possible use of stem cells is in the treatment of pulmonary hypertension. In a recent paper (Spees et al. Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension. FASEB J. 2007 Nov 21) the potential of bone marrow stem cells to treat this condition was assessed.

Female rats were treated with monocrotaline to induce pulmonary hypertension and were subsequently administered bone marrow cells from GFP syngeneic male rats. Male cells were identified in female lung. The male-derived cells consisted of interstitial fibroblasts, myofibroblasts, pulmonary epithelial cells (Clara cells), vascular endothelial cells, and smooth muscle cells.

Since pulmonary hypertension induces a high workload on the right ventricle, ventricular hypertrophy was observed in the rats that were treated with monocrataline. There was a higher number of bone marrow derived cells in the right ventricle as opposed to the left ventricle in the monocrataline treated animals. Some of the bone marrow derived cells were seen to express cardiac and muscle phenotype. The differentiated cells expressed karyotypic normality.

These data support further investigation into the use of bone marrow derived stem cells for the treatment of pulmonary hypertension.


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5 Comments | Add Comment

Dhanjaya (Bangalore) said...

Created 2009-03-04 02:46:49 EST
I am Dhanjaya suffering primary pulmonary hypertention since five years and acute renal failure since 2months, is iam elgible for adult stem cell therapy and please send full detials and show mercy on me.
- 1 -

Christineball33 said...

Created 2009-03-04 10:43:09 EST

Dear Dhanjaya,

You may want to contact the Cellmedicine Institutes (www.cellmedicine.com).  They have been using numerous stem cell therapies for many conditions, including pulmonary hypertension.

Cellmedicine is much better than other stem cell clinics which talk a lot but do very little or do not have a history or track record of success.

Whenever you talk with stem cell clinics ask a lot of questions since some are really good oboth others not so good.

 

Christine

- 2 -

Dr Sunil W said...

Created 2009-05-01 15:25:27 EST

Dear Dhananjay,

                          YOUR CONDITION OF PRIMARY PULMONARY HYPERTENSION CAN BE TREATED WITH AUTOLOGOUS STEM CELL TRANSPLANT. U CAN CONTACT INTERVENTION CLINIC AND SPECTRUM CELL CLINIC IN MUMBAI. MAIL ME prati.sunil@gmail.com, call me on 09819445690. 

Dr Sunil Waghmare.

md, dmre, fellow ISVIR, macp, facp.

Interventional Radiologist and stem cell therapist.

- 3 -

davo99 said...

Created 2010-10-21 17:33:37 EST
My son is 2 1/2 he was disgnosised with PH at 5 months additionally he has a VSD which they say casued the PH in the 1st place. Is there anything out there; stem cells, growth hormone (thought is increase the lung capacity faster than body can adjust to the pressure) or research studies that I need or should be on top of?
- 4 -

Thomas said...

Created 2012-10-17 05:57:21 EST
Javier Lopez has had some good results with autologous SVF
- 5 -

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