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Generating lung epithelium from cord blood stem cells

Monday December 10th, 2007 @ 02:59:41 EST

From Category: Differentiation

Burlington, VT -

Generation of lung epithelium de novo would be very useful in the treatment of chronic lung diseases. Unfortunately previous attempts to do this have not been extremely successful. In a recent study (Sueblinvong et al. Derivation of Lung Epithelium From Human Cord Blood-Derived Mesenchymal Stem Cells. Am J Respir Crit Care Med. 2007 Dec 6) human cord blood stem cells were used to generate lung epithelium in vitro and in vivo.

The investigators generated cord blood derived mesenchymal stem cells by cultivation of adherent cells. The mesenchymal stem cells were subsequently treated with retinoic acid and keratinocyte growth factor, which resulted in the differentiation into cells that expressed various markers of pulmonary epithelium such as CCSP and CFTR.

Injection of the cells into immune deficient mice resulted in some of the cells integrating with the lung and expressing human proteins in the mouse lung.


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1 Comment | Add Comment

Christineball33 said...

Created 2008-03-30 20:54:13 EST

It is one thing to generate epithelium de novo but how in the world would one get it to integrate into the tissue where it is really needed?  This is one of the problems I have with a lot of the stem cell studies.  If you make a tissue artificcially, fine, but what in the world are you going to do with it besides publish a neat paper? You will just keep it in your hand and show it to your friends?

 We as scientists have to start thinking not just how to make tissues with stem cells but also how to implant the tissue.

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