Class: Use (242)
Telomerase promoters sequences for screening telomerase modulators
Patent Number: 7,378,244Division of most mammalian cells is accompanied by reduction in the length of telomeres, which is responsible in part for cellular senescence and death. Some cells, particularly stem cells and cancer cells, express the enzyme telomerase and are not restricted by the "Hayflick Limit". Some data exists to support the concept...
1 Comment
Cosmetic compositions
Patent Number: 7,405,195The current patent covers a cosmetic generated using a variant of stromal derived factor (SDF-1) which the inventors termed stem cell active factor (SCAF). The natural function of SDF-1 is to call in stem cells to injured tissue, for example, after a heart attack there is a surge of SDF-1 which is involved in mediating mobilization of stem cells from the bone... One of the problems with cell therapy after injury is the possibility of accelerating scar tissue formation. The current patent teaches the use of X-rays, administered by parallel micro-beams at doseages that are sufficient to remove inhibitors of regeneration.
The patent also discloses the use of exogenous stem cells in combination with the X-rays in order to accelerate healing.
It has always been the belief of StemCellPatents.com that the future of stem cell therapeutics is not only in the development and use of stem cell types, but the integration of stem cells with other modalities to attain synergy. For example, while FDA/EMEA development of cellular product candidates takes years and hundreds of millions of dollars, the same, or very... The issued claim in the current patent covers a method of diagnosing a motor neuron disease based on sequences associated with mutations in the neuropathy target esterase (NTE) gene. If one reads the specification, descriptions of treatments based on inhibiting expression of the mutated NTE gene using techniques such as siRNA are disclosed. Genetic complementation using stem cells are also... Vascular aneurysms are thinning of blood vessel walls, which is usually associated with vessel trauma, non-specific degeneration, atherosclerosis, or infection. The term "aneurysm" comes from the Latin "aneurysma" which means "dilation". Aneurysms are hazardous because of the potential to burst. They are usually prevelant in the aorta or cerebral arteries.
The current patent provides... Genetic manipulation of ES cells provides a powerful method for developing unique cell line models of various human diseases. More clinically applicable is the possibility of specifically producing mutations in genes that elicit rejection of ES cells, so as to generate "universal donor" stem cells.
This patent teaches ways of generating mutations in exons of genes in ES cells by... Xenotransplantation offers the possibility of using animal organs either permanently as a substitute for human organs, or as a "bridge" until a suitable human organ may be found. The most significant barriers to xenotransplantation appear to be innate in nature. Specifically, the first barrier is the hyperacute rejection, which occurs because of a very high level of... The positive effects of stem cells in cardiac conditions is supported by many clinical trials. Efficacy has been demonstrated by both intracoronary administration, as well as intravenous administration of bone marrow and mesenchymal stem cells, respectively. In this patent, Medronics was granted some pretty far-reaching claims. This is a representative claim "A... Classically cord blood transplantation is used for the treatment of hematological disorders in which the recipient hematopoietic stem cell compartment is ablated (by chemotherapy and/or radiation) and the donor cord blood cells are used for hematopoietic rescue. However the use of cord blood in the area of regenerative medicine (non-hematopoietic purposes) does not require destruction... 1 Comment
Methods for assisting recovery of damaged brain and spinal cord using arrays of X-ray microplanar beams
Patent Number: 7,158,607
Methods for assisting recovery of damaged brain and spinal cord using arrays of X-Ray microplanar beams
Patent Number: 7,305,064
Compositions and methods for detecting and treating motor neuron disorders
Patent Number: 7,384,748
Compositions, systems and methods for treatment of defects in blood vessels
Patent Number: 7,201,918
Genome mutation by intron insertion into an embryonic stem cell genome
Patent Number: 7,205,148
Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation
Patent Number: 7,378,569
Myocardial stimulation
Patent Number: 7,349,740
Treatment of retinitis pigmentosa with human umbilical cord cells
Patent Number: 7,413,734