Class: Use (255)
Method of treating coronary artery disease by administering a recombinant FGF
Patent Number: 6451303There are more than 20 members of the fibroblast growth factor family. Many of the FGF proteins are involved in activation of stem cell proliferation, as well as induction of angiogenesis. This patent covers the treatment of coronary artery disease, for example ischemia induced by it...through the stimulation of angiogenesis by administration of
Transplantation of neural cells for the treatment of chronic pain or spasticity
Patent Number: 6444205This patent covers administration of GABA producing neurons or neural stem cells from a fetus into a patient with chronic pain or spasticity. This patent covers not only human donor sources but also porcine. The ability to generate different types of pigs through genetic engineering may allow for some of these approaches to enter the clinic. One such particular...
Methuselah gene, compositions and methods of use
Patent Number: 6303768Methuselah is a gene, which certain variants of it are associated with life extension. The mechanisms of action are not completely known, however it appears that it acts along the pathway of reducing cellular metabolic stress.
Methods for treating cancer using allogeneic lymphocytes without graft vs host disease activity
Patent Number: 6213127This patent teaches ways of administering allogeneic lymphocytes that have been treated chemically or with radiation so as to elicit an antitumor effect while at the same time not causing graft versus host.
Neural stem cells and use thereof for brain tumor therapy
Patent Number: 7,186,409The current patent teaches that exogenous neural stem cells can migrate to the area of various brain cancers. The patent covers the use of neural stem cells as a trojan horse to carry enzymes that activate prodrugs into active drugs in proximity to a tumor in order to induce cancer cell death.
Treatment for diabetes
Patent Number: 6558952This patent teaches how to induce endogenous islet stem cells to multiply through administration of gastrin together with a ligand of the EGF receptor such as TGF alpha. One of the principles behind the current company doing clinical trials with this, Dr Tony Cruz, is also involved in the company Stem Cell Therapeutics, which is performing...
Method of isolating ependymal neural stem cells
Patent Number: 7,279,332It is believed that neural stem cells are found in large quantities in the ependyma (the thin epithelial membrane lining the ventricular system of the brain and the spinal cord canal). The ependyma is one of 4 types of neuroglia and its primary function is the production of cerebrospinal fluid. The current patent covers the assessment of test compounds for modulation of...
Use of multipotent neural stem cell progeny to augment non-neural tissues
Patent Number: 6638501This patent covers the use of neural stem cells for enhancing activity of hematopoietic stem cells. This patent attests to the similarity, if not synergy, between the neural stem cell system and the hematopoietic stem cells system.
Methods and compositions for screening for altered cellular phenotypes
Patent Number: 7056687This patent is useful for drug development. It teaches ways of inducing gene expression in cells (including stem cells) and using the specifically modified cells for screening of drug libraries. The invention itself is not specific to stem cells, so therefore we will not describe it in detail. The patent has 3 independent claims. Specifically: "A method of screening for cells having an...
Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
Patent Number: 6866842This patent teaches the use of skeletal myoblast, muscle stem cells, for treating urinary incontinence. The cells may be used without modification, or may be genetically engineered to express therapeutic genes. Examples of therapeutic genes include nerve growth factor, nitric oxide, etc.