Class: Use (255)
Genetic engineering of cells to enhance healing and tissue regeneration
Patent Number: 6077987This patent covers the induction of healing through administration of mesenchymal stem cells alone, or mesenchymal stem cells after transfection with other genes.
Device and method for regeneration and repair of cartilage lesions
Patent Number: 6514514This patent covers a matrix that can be used for cartilage repair comprising of biodegradable materials, as well as cytokines and growth factors.
Computer-based mixed-use registry of placental and umbilical cord stem cells
Patent Number: 5993387This patent in a way smells like a method of doing business patent. Interestingly it was actually filed before the "State Street v Signature Financial" case. Essentially this patent covers a computer registry for matching cord blood to donors. I wonder if this patent is actually being enforced today?
Cardiac muscle regeneration using mesenchymal stem cells
Patent Number: 6387369This patent covers the use of mesenchymal stem cells for cardiac repair, specifically after myocardial infarction. Mesenchymal stem cells are currently in clinical trials for this application. In fact the same company to which this patent is assigned to, Osiris Therapeutics, has actually published positive double blind data on patients post infarct treated with allogeneic,
Method of treating huntington's disease using HNT neurons
Patent Number: 6254865This patent covers the use of neural terminally differentiated teratocarcinoma cells (hNT) for the treatment of Huntington's disease. This technology has actually been used in clinical trials.
Methods of enhancing functioning of the upper gastrointestinal tract
Patent Number: 6051557This patent covers the use of GLP-2 for stimulation of stem cells in the upper GI tract. This patent is useful for treatment of pathologies associated with malfunction of these cells, such as mucositis, gastritis, or various types of injuries.
Methods for the modulation of the growth of collateral arteries and/or other arteries from preexisting arteriolar connections
Patent Number: 6592862This patent essentially covers the induction of angiogenesis using the chemokine MCP-1. This patent would most likely synergize by combining administration of MCP-1 with hematopoietic stem cells and/or endothelial precursor cells.
Bone marrow as a site for transplantation
Patent Number: 6463933This patent teaches how to perform transplantation of cells directly into the bone or bone marrow. The patent specifically claims the transplantation of hepatocytes or islet cells. It is known that the bone marrow is an immune priviledged environment, at least to some extent, therefore this idea is really novel. Sakaguchi in Japan was at one time publishing that intra-bone transplant of...
Cationic liposome delivery of taxanes to angiogenic blood vessels
Patent Number: 7,238,369Tumors are highly dependent on angiogenesis. The stem cell compartment is believed to supply circulating angioblasts which leave the bone marrow and home into tumors to support formation of new blood vessels. This patent covers a unique method of specifically targeting chemotherapeutic taxanes to areas of angioblast mediated angiogenesis through the use of cationic lipids. The patent...
Method of using exendin and GLP-1 to affect the central nervous system
Patent Number: 5846937This patent may be interesting for Amylin from San Diego to look at. Why it is interesting is because, I believe, Amylin actually has taken some of the compounds described in this patent to the clinic. This patent teaches the use of GLP-1 and/or exendin-4 for modulation of central nervous system activity.