Class: Use (242)
Tissue-engineered bone repair using cultured periosteal cells
Patent Number: 5700289This patent teaches that in some situations, cells from the periosteum can be grown and used as a "stem cell like" population for the treatment of bone defects.
Materials and methods relating to the transfer of nucleic acid into quiescent cells
Patent Number: 6723561The early hematopoietic stem cells are usually non-proliferating, additionally, intermediately developed hematopoietic stem cells treated with stem cell inhibitors such as TGF-beta, also do not proliferate. This causes a problem for gene therapy since most gene therapy vectors require the cells to be proliferating for appropriate transfection. This patent teaches...
Methods and compositions to improve germ cell and embryo survival and function
Patent Number: 6140121This patent provides compounds that are capable of increasing the viability of germ cells and embryos both in vitro and in vivo.
Cloning ungulates from a quiescent donor cell
Patent Number: 7,232,938This is one of the original cloning patents from the inventor of Dolly the sheep :) It covers a method of cloning an ungulate comprising: (i) providing a quiescent ungulate cell as a diploid donor cell; (ii) fusing the diploid donor cell to an enucleated oocyte recipient of the same species as the donor cell, thereby obtaining a reconstituted cell; (iii) activating the oocyte...
Serial nuclear transfer of ungulate embryos
Patent Number: 7,321,075This patent covers a method of cloning in which the nucleus is transferred across generations. The first claim exemplifies the basis of what is covered, which is essentially "serial nuclear transfer" by a) taking a transgenic nucleus b) culturing the nucleus in an embryo c) splitting the embryoin into cells d) taking the nucleus from the cells and using it to insert into oocytes in order...
Ungulates produced by nuclear transfer of G1 cells
Patent Number: 7,304,204This patent is one of Ian Wilmut's family of patents covering various aspects of the cloning procedure. In this particular patent cloning of an ungulate (e.g. pigs, horses, sheep, or goats) is covered through the use of nuclear transfer in which the donor nucleus is in the G1 phase of the cell cycle and the recipient oocyte is blocked in the metaphase II phase and enucleated.
Medicinal preparation based on fetal cell suspension having immune substituting effect for patients with acquired immune deficiency syndrome (HIV infection)
Patent Number: 6184033This patent teaches the administration of fetal cells, including stem cells, for the treatment of HIV infection. Various stem cells are known to secrete anti-inflammatory compounds such as TGF-beta. One possible mechanism of action is that stem cells secrete these antiinflammatory compounds, which in turn inhibit NF-kappa B, which does not...
Methods of screening for a candidate compound able to bind to CD34.sup.+ cells
Patent Number: 5965457This patent covers methods of screening for identifying which compounds bind to purified CD34+ cells. Since CD34+ cells are stem cells of the hematopoietic lineage, by identifying agents that bind to them it is possible to generate novel ways of purifying and identifying them.
Method of treating heart failure using leukemia inhibitory factor antagonists optionally with endothelin antagonists
Patent Number: 5837241This patent covers antagonizing either or both the endothelin receptor and the LIF receptor. Methods of action by which this combination inhibits heart failure may have to do with modulation of stem cell function.
Use of leukemia inhibitory factor and endothelin antagonists
Patent Number: 6156733This patent teaches how to treat heart failure by administration of antagonists to endothelin and LIF.