Class: Use (241)
Methods of treating disorders of the eye
Patent Number: 6750196This patent teaches expansion of retinal cells, and stem cells thereof, through the administration of proteins called neuroregulins. The patent is useful for treatment of a variety of ocular degenerative diseases.
Mesenchymal stem cells for cartilage repair
Patent Number: 6214369This patent covers the use of mesenchymal stem cells for generation of bone and cartilage. It is interesting that Osiris has patents in this area as well.
Mesenchymal stem cells for cartilage repair
Patent Number: 5906934This patent covers the use of mesenchymal stem cells for generation of artificial bone and cartilage. It is interesting that this patent was issued in light of Osiris's domination of the field of mesenchymal stem cells. This patent should be read in light of the other mesenchymal stem cell patents.
Development and use of human pancreatic cell lines
Patent Number: 6110743This patent covers islet stem cells and cell lines that generate islet cells. This patent could be useful for the treatment of type 1 diabetes. In some cases, it may be beneficial to encapsulate the cell lines so as to avoid immune mediated rejection. Alternatively these cells would provide a great source of tissue for using the Edmonton Protocol.
Recombinant vectors for reconstitution of liver
Patent Number: 5980886This patent covers ways of transfecting liver cells in vivo through the induction of liver stem cell activation by first transfection with a gene such as tPA or uPA, and then once the cells are proliferating, transfection with another gene that is therapeutic.
Myoblast therapy for cosmetic treatment
Patent Number: 7,341,719One of the regenerative cells of the muscle is the myoblast. These cells essentially act as muscle stem cells, having the ability to multiply after injury and form muscle by fusing with other myoblasts. Myoblasts are very practical for cell therapy since they may be easily extracted from autologous sources and grown in vitro. Additionally, there is some evidence that myoblasts, upon fusing...
Leukemia inhibitory factor from mammalian species and use thereof to enhance implantation and development of embryos
Patent Number: 5962321This patent teaches the use of the cytokine LIF for increasing the rate of implantation of embryos. This patent is useful for generation of knockout and transgenic mice.
Cell compositions for use in transplantation
Patent Number: 6068836This patent teaches how to transfect quiescent hematopoietic stem cells. Transfection of these primitive stem cells should be useful for a variety of gene therapy applications including treatment of several metabolic diseases such as Krabbe Disease.
Methods for treatment of pulmonary disease using GM-CSF
Patent Number: 6019965This patent teaches that the administration of the clinically-used cytokine GM-CSF is useful for the treatment of alveolar proteinosis. This patent would be great to use in combination with systemically administered stem cell therapy since most stem cells given intravenously end up in either the lung or the liver.
Bone precursor cells: compositions and methods
Patent Number: 5972703This patent teaches the isolation, expansion, and use of bone stem cells that are separated from bone marrow cells.