Class: Use (242)
Bone precursor cells: compositions and methods
Patent Number: 5972703This patent teaches the isolation, expansion, and use of bone stem cells that are separated from bone marrow cells.
Gene therapy by administration of genetically engineered CD34.sup.+ cells obtained from cord blood
Patent Number: 6984379This patent covers the use of autologous cord blood CD34 cells transfected with the adenosine deaminase gene for the treatment of severe combined immunodeficiency (SCID). The patent has 3 independent claims, the first covering a method of expressing a therapeutic agent in a human (but specifically restricted to adenosine deaminase), the second a method of treating a...
Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2
Patent Number: 7,186,688VEGF (vascular endothelial growth factor) is a potent endothelial cell mitogen that has previously been used in clinical trials for therapeutic angiogenesis. The current patent covers the use of specific fragments of VEGF for the stimulation of angiogenesis and the treatment of various conditions. Specific conditions for treatment include...
Materials and methods for management of hyperacute rejection in human xenotransplantation
Patent Number: 7,201,899Xenogeneic transplants from lower animals to humans are prevented in part by the hyper-rejection phenomena which ensues as a result of preformed antibodies against alpha-gal epitopes. Alpha-gal epiptopes are generated as a result of activity of the enzyme alpha.-1,3 galactosyltransferase. This patent covers cells, including ES cells, for generation of knockout pigs or organs which lack...
Pharmaceutical preparation based on fetal suspension and methods of treating acquired immune deficiency syndrome (HIV injection)
Patent Number: 5811089This patent covers the injection of fetal hematopoietic organs, and extracts thereof, for the treatment of HIV.
Myocardial grafts and cellular compositions
Patent Number: RE37,978This patent is useful for anyone who is performing embryonic stem cell differentiation applications and desires a method of purifying unique differentiated cells from the embryonic stem cell. Since embryonic stem cells spontaneously differentiate into various lineages depending on culture conditions, this patent provides means of "fishing out" cells based on activation of cell-specific...
Myocardial grafts and cellular compositions useful for same
Patent Number: 6818210This patent teaches how to generate a myocardial graft using embryonic stem cells that have been induced to differentiate into the cardiac lineage. This patent is especially useful for post myocardial infarction in which scar tissue replaces functional myocardium resulting in decreased cardiac output. Numerous methods have been previously described for generation of myocardial cells from...
Bone marrow transplantation
Patent Number: 5806529This patent teaches that administration of "mega-dose" hematopoietic stem cell grafts may be useful for circuventing the requirement of completely ablating the recipient immune system. Use of this patent may allow for reduced neutropenic times and increased survival after bone marrow transplantation.
Non-lethal methods for conditioning a recipient for bone marrow transplantation
Patent Number: 5635156This patent teaches how to perform bone marrow transplantation, or transplantation of stem cells with hematopoietic potential, without completely ablating the recipient hematopoietic system. The patent uses various antibodies to not-completely deplete the host, but just enough so that the stem cells administered are not completely cleared away.
Infusion of neutrophil precursors for treatment of neutropenia
Patent Number: 6010697This patent teachs ways of overcoming neutropenia by administration of committed stem cells that differentiate into the neutrophil lineage. This work has the potential to be very beneficial in nuclear accidents where a quick supply of neutrophils is needed. The biggest barrier is whether allogeneic neutrophil committed stem cells may be used or whether the stem cells strictly have to be...