Class: Use (244)
Non-lethal methods for conditioning a recipient for bone marrow transplantation
Patent Number: 5635156This patent teaches how to perform bone marrow transplantation, or transplantation of stem cells with hematopoietic potential, without completely ablating the recipient hematopoietic system. The patent uses various antibodies to not-completely deplete the host, but just enough so that the stem cells administered are not completely cleared away.
Infusion of neutrophil precursors for treatment of neutropenia
Patent Number: 6010697This patent teachs ways of overcoming neutropenia by administration of committed stem cells that differentiate into the neutrophil lineage. This work has the potential to be very beneficial in nuclear accidents where a quick supply of neutrophils is needed. The biggest barrier is whether allogeneic neutrophil committed stem cells may be used or whether the stem cells strictly have to be...
Infusion of neutrophil precursors for treatment of neutropenia
Patent Number: 5846529This patent covers ways of treating neutropenic patients through administration of stem cells that are committed to differentiating into neutrophils. This patent is useful for the treatment of patients that are suppressed in terms of white blood cell numbers.
Method of regenerating articular cartilage
Patent Number: 5368051This patent teaches how to use growth hormone, as well as other factors for the repair of articular cartilage. The method is useful for developing not only therapeutic kits, but also as a stepping stop for new methods of using stem cells, both endogenous and exogeneous in cartilage repair.
Use of neuro-derived fetal cell lines for transplantation therapy
Patent Number: 5753491This patent covers fetally derived neuronal stem cells, alone, and after transfection with therapeutic genes. These stem cells may be transfected in order to secrete trophic factors that would allow endogenous brain stem cells to proliferate. On the other hand, they may be transfected with anti-apoptotic genes such as Xiap. Xiap transfection would allow the cells to maintain viability.
Modulation of immune responses in blood-borne mesenchymal cells
Patent Number: 6054121If I read this currently, this patent seems to cover the use of blood mesenchymal stem cells for stimulation of immune responses to antigens. This is the opposite to what the current knowledge of mesenchymal stem cells is...that being that they are immune suppressive. If these cells were immune stimulatory then the current Phase III trials for graft versus host...
Treatment for juvenile diabetes
Patent Number: 6288301This patent teaches how to treat diabetes by the activation of endogenous stem cells through administration of gastrin and EGF. This patent is in clinical trials.
Method for increasing neutrophil populations using in vitro-derived human neutrophil precursor cells
Patent Number: 5888499This patent covers ways of generating neutrophil-committed stem cells. These neutrophil committed stem cells are useful for prevention of infection after myeloablation.
Allogeneic and xenogeneic transplantation
Patent Number: 6911220This patent is for a very interesting idea. The induction of tolerance by ablating recipient T cells and recipient thymus, introducting a donor fetal or neonatal thymus, and allowing recipient T cells to mature with the donor thymus. This is based on the whole concept of inducing negative selection so that the recipient T cells will not kill the donor graft...but instead recognize it as...
Hematopoietic stem cell specific gene expression
Patent Number: 5556954This patent covers the promoter for CD34. CD34 is a classical marker of stem cells, not only of the hematopoietic type but also of the hepatic type. CD34 is highly glycosylated and acts as an adhesion molecule. Mice that are knocked out for CD34 still have hematopoiesis, however the stem cells to not migrate...