Class: Use (236)
Endothelialization of vascular surfaces
Patent Number: 7,172,758Endothelial injury may be induced by numerous means. One clinically relevant situation is endothelial injury caused by balloon injury during percutaneous transluminal coronary balloon angioplasty. This injury causes restenosis, which eventually requires re-intervention. This patent teaches ways of accelerating the healing of the injured tissue by essentially “sticking” the endothelial...
Devices and methods for treating defects in the tissue of a living being
Patent Number: 7,166,133Non-healing bone injuries pose a significant burden on our medical system. This new patent owned by the Kensey Nash Corporation provides a novel method for accelerating bone healing through providing an implantable matrix that contains collagen and "osteoinductive" factors. These factors may be proteins or cells according to the invention. The first independent claim of the patent covers...
Use of erythropoietin for the preventive or curative treatment of cardiac failure
Patent Number: 7,335,490The use of erythropoietin for non-hematopoietic purposes has been increasing in the last couple of years. One obvious example is the Canadian company Stem Cell Therapeutics (sss.v) which is using erythropoietin together with human chorionic gonadotropin for treatment of patients post-stroke. Other uses of erthrypoietin include direct
Antibody to stem cell factor
Patent Number: 7,285,640This is a composition of matter patent on an antibody to stem cell factor. Since stem cell factor is involved in asthma, this is one of the proposed uses in the specification. Given that stem cell factor is also involved in numerous malignancies such as GIST, this patent may have many uses.
Method of culturing cells to produce a tissue sheet
Patent Number: 7,166,464The ability to generate monolayers of cells is important for a variety of tissue engineering applications. Most notably is the need to generate monolayers that can be placed on medical devices such as stents in order to allow increased compatibility and decreased rates of restenosis. The current patent teaches ways of culturing cells, including stem cells, in a monolayer and methods of...
Composition and method for treating graft-versus-host disease
Patent Number: 7,173,016Graft versus host disease (GVHD) is one of the major limitations of bone marrow, or for that matter, any type of allogeneic hematopoietic stem cell transplant. Essentially, GVHD is the result of donor derived T cells attacking the allogeneic recipient. Previously attempts were made to reduce GVHD by “purging” the stem cell graft of T cells...
Production of cultured human mast cells and basophils for high throughput small molecule drug discovery
Patent Number: 7070996This is a patent covering the use of CD34+ generated mast cells for drug screening. Since technologies for generating mast cells existed in the prior art (for example, as early as 1991 it was known that CD34+ cells can differentiate into mast cells: Kirshenbaum AS, et al. Demonstration of the origin of human mast...
Materials and methods for nerve grafting, selection of nerve grafts, and in vitro nerve tissue culture
Patent Number: 6972168This patent teaches ways of generating an plethora of compounds which are useful for regeneration of damaged nervous system tissue. Specifically, the patent has 2 independent claims. The first covers growing nerves in conditions that are not associated with degeneration, then killing the nerves, harvesting the material, and introducing the material into an area where damaged neurons are...
Endothelial precursor cells for enhancing and restoring vascular function
Patent Number: 7,135,171Numerous ways exist of augmenting angiogenesis. These range from administration of cytokines such as FGF (US Patent #6451303) to administration of cells (US Patent 5980887). The current patent teaches the administration of endothelial progenitor...
Methods for treatment of vascular disease and device for preparation of an autologous composition for treating vascular disease
Patent Number: 6623733While some patents use cell supernatant for induction of biological activities, this patent goes all out and uses cell lysates! This patent covers the use of various cell lysates, including of stem cells, in order to augment stem cell proliferation as well as angiogenesis.