Class: Use (241)
Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof
Patent Number: 7,141,428Stem cells are increasingly seen as a source for the generation of new neurons. In this patent, ways of protecting neurons and stimulating axon regrowth are thought. Specifically, the patent deals with two GTPases called Rho and Rac. Rac activation causes axon spreading, while Rho activation causes axon retraction. In many neurodegenerative diseases, axons are...
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Treatment of disease by inducing cell apoptosis
Patent Number: 7,402,567Hepatic fibrosis is associated with overproduction of collagen by stellate cells, as well as killing of hepatocytes by these cells.
In some situations stem cells have demonstrated positive effects in clinical liver failure, both bone marrow stem cells, as well as mobilized peripheral blood stem cells.
One mechanism...
Vaccine immunotherapy for immune suppressed patients
Patent Number: 7,182,942Cancer vaccines have had a checkered past. This is primarily because numerous experimental approaches that demonstrated animal efficacy could not be translated into humans. Since numerous animal models are in-bred and involve carcinogenesis that is unnaturally “fast” (e.g. either a cell line is injected or huge amounts of carcinogens are administered) it is likely that these models do not...
Biological pacemaker and implantation catheter
Patent Number: 6690970This patent covers the use of stem cells and products of stem cells as "biological pacemakers" so as to ensure that the electrical pulses of the heart are appropriately coordinated.
Methods of treating anosmia and repopulating olfactory nerves with retinoids
Patent Number: 6506801This patent teaches the use of retinoids to stimulate olfactory stem cells in order to restore the sense of smell to an animal in need thereof. The use of retinoids for stimulation of stem cell differentiation is well known and is actually therapeutic in various types of cancer, in which the malignant cell is subjected to "differentiation therapy" such that it loses its malignancy.
Methods and compositions for tissue regeneration
Patent Number: 7,144,729This patent covers a novel method of treating wounds through "spraying" allogeneic cells, together with fibrinogen and thrombin, in order to secrete various growth factors, including factors that stimulate stem cells, so as to accelerate wound healing. Systems for inducing tissue regeneration, as well as kits are provided. Basically, the independent claim covers a two part administration of...
Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue
Patent Number: 6878371This is a very important patent for the clinical trials ongoing right now that are administering bone marrow autolous stem cells into the heart of patients in order to stimulate angiogenesis. This paten is definately worthy of detailed reading and understanding in light of existing clinical research in this area.
Composition and method for the repair and regeneration of cartilage and other tissues
Patent Number: 7,148,209Repair of cartilage is an area of active investigation using a wide variety of approaches, including bone marrow mesenchymal stem cells and various progenitor cell types. In this patent, methods of inducing cartilage regeneration are disclosed through administration of a solution that contains a mixture of various blood components and polymers. In certain embodiments the polymers are liquid...
Use of human embryonic stem cells for drug screening and toxicity testing
Patent Number: 7041438This is a very broad patent that essentially covers all drug screening using a specific type of stem cells. The inventors describe these stem cells as "primate Pluripotent Stem cells" (pPS cells), thus including pre-embryonic, embryonic, or fetal tissue-derived cells that can be induced to differentiated into progeny of the three germinal layers: endoderm, mesoderm, and ectoderm. This...
Autogenous cell patch cardio myoplasty and advanced muscle graft implantation system
Patent Number: 6435190This patent teaches what appears to be a surgical method for producing an autograft that can cover lesions in the heart. This is important since after a heart attack, there is scar tissue formation, and the heart starts to lose function. The patent also covers ways in which autologous stem cells may be administered.