Class: Use (242)
Treatment of brain damage
Patent Number: 6569421This patent teaches how to treat neurological damage through administration of stem cells into the contralateral hemisphere of the brain.
Methods and compositions for healing heart wounds
Patent Number: 6852706This patent teaches activation of cardiac healing processes through reducing levels of thyroid hormone. This patent seems to depart substantially from the common notion that thyroid hormone is actually beneficial for the heart. For example, it is published that reducing thyroid hormone by administration of propylthiouracil actually leads to cardiac atrophy, angina and general deterioration...
Human cord blood as a source of neural tissue for repair of the brain and spinal cord
Patent Number: 7,160,724There is currently great interest in the use of cord blood stem cells for neuroregenerative purposes. This patent covers the ex vivo growth of cord blood cells in EGF, FGF2, NGF, and retinoic acid in order to generate a population of cells that contain neuronal-like properties. Evidence of activity of these neural precursors is provided in the examples section...
Composition and method for inducing and enhancing a telomerase reverse transcriptase-reactive cytotoxic T lymphocyte response
Patent Number: 7,388,071Telomerase is an enzymatic complex that repairs the telomeric ends of chromosomes so as to allow certain cells to escape senescence. Various stem cells, including some adult stem cells, express telomerase. Most importantly, tumors express this complex and it is what allows them to continue proliferating without undergoing senescence.
A very interesting...
Preparation and xenotransplantation of porcine islets
Patent Number: 7,122,177This patent covers the use of xenogeneic islet cells derived from fetal or neonatal pigs -20 to +10 days after birth, treating the cells with nicotinamide, lignocaine and a quinolone antibiotic, in order to generate a population of cells that may be encapsulated and used for treatment of diabetes in a human.
Method of transplanting in a mammal and treating diabetes mellitus by administering a pseudo-islet like aggregate differentiated from a nestin-positive pancreatic stem cell
Patent Number: 6866843This patent teaches extraction of pancreatic stem cells based on expression of nestin...expansion of the cells into islet-like cells...and transplantation of the cells for treatment of diabetes. The problem is how much expansion can one achieve? Since there is a SEVERE shortage of donor pancreas'. The other problem, of course, is the need for immune...
NK-2 homeobox transcription factor
Patent Number: 7,183,397The NK-2 homeobox transcription factor family are responsible for tissue specification and are found in a variety of stem cells. The ability to modulate such transcription factors has numerous applications in the area of stem cells since such modulation could be used to guide differentiation into specific tissues. The current patent claims the composition of matter for one such family...
Use of treosulfan for patient conditioning before bone marrow or blood stem cell transplantation
Patent Number: 7,199,162During bone marrow or peripheral blood stem cell transplant, it is typical to perform preconditioning of the recipient. This is done in order to wipe out host derived hematopoiesis, and to "make room" for the donor stem cells. Additionally, in conditions of hematological neoplasia, recipient conditioning is performed with the idea of eradicating cancer cells. Numerous protocols and...
Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
Patent Number: 7,399,751This is a patent with priority in 1999 describing the use of genetically modified Sertoli cells for immune protection of implanted cells AND the use of the Sertoli cells themselves as the vector...genetic engineer with any gene is covered.
This patent is part of the Canadian company Sernova's (CDNX:SVA.V) potent intellectual property...
Method of preparing suppressor T cells with allogeneic mesenchymal stem cells
Patent Number: 6281012This patent covers the use of mesenchymal stem cells to generate T suppressor cells in general. Specifically it mentions that CD8 positive T cells can be turned into suppressor cells by contact with mesenchymal stem cells. Usually, T suppressor cells are called T regulatory cells and this refers to CD4+ CD25Inventors: McIntosh, Kevin (Ellicott City, MD); Klyushnenkova, Elena (Baltimore, MD)