Class: Expansion (410)
Matrix-targeted fusion polypeptides for tissue regeneration and wound healing
Patent Number: 7,459,541This patent covers a series of fusion proteins that are generated with selectively to bind collagen. The inventors believe that since various forms of collagen are exposed during injury, the specific targeting of "repair" proteins to the injuried tissue will augment the healing process.
Specifically the inventors target the "repair proteins": insulin...
Methods for producing and preparing cells for cell therapy
Patent Number: 6465248This patent teaches ways how to culture neurons in order to obtain certain phenotypes. One type of neuron that is obtained by using the culture conditions thought by this invention is a dopamine secreting neuron. This invention is owned by the company Prescient NeuroPharma which appears to be a Canadian venture-backed company.
Efficient culture of stem cells for the production of hemoglobin
Patent Number: 6361998This patent teaches how to generate large amounts of erythrocytes by specifically culturing hematopoietic stem cells with cytokines such as IL-3, Stem Cell Factor, and EPO.
Method for enhancing hematopoiesis
Patent Number: 6821513Cell culture systems and methods for organ assist devices
Patent Number: 6759245Ex vivo culture of stem cells is important for the generation of artificial organs. This patent teaches culture of stem cells and precursor cells using a unique culture set up that allows for proper differentiation of cells in an in vivo like setting. The patent is primarily targeted towards the generation of hepatocytes.
Methods of making conditioned cell culture medium compositions
Patent Number: 6372494This patent teaches how to generate cell conditioned media. The unique part about this patent is that the cells used to condition the media are grown in three dimensional culture.
Neuroprotective composition and uses thereof
Patent Number: 6858646Oxidative stress plays a very important role in the ability of stem cells to survive. Specifically, stem cells prefer to reside in areas of relative hypoxia, and are particularly senstive to oxidative stress. This patent teaches that use of pyruvate, and other antioxidants in order to protect neurons, and stem cells of neurons, from damage. This patent may be used to treat, for example...
Methods for promoting growth of bone, ligament, and cartilage using zvegf4
Patent Number: 6866991This patent describes the use of zvegf3, a platelet derived growth factor homologue for expansion of various stem cells, including bone marrow stem cells.
Loop peptide and TGF.alpha. for stimulating stem cell proliferation and migration
Patent Number: 7,365,172Stem cells need to be maintained in a quiescent state when they are not needed to make new cells. This is because if stem cells were consistently proliferating then there would be a high propability of mutations, thus leading to cancer. One of the methods that stem cells maintain themselves in a non-proliferating state is through autocrine secretion of inhibitory factors. ...
Loop peptide and TGF.alpha. for stimulating stem cell proliferation and migration
Patent Number: 6764683Mucositis is a big problem in cancer patients taking chemotherapy and radiation therapy, in part due to the effect of these therapies on the epithelial stem cell pool. This patent teaches the usefulness of transforming growth factor alpha on preventing this condition by its ability to protect the stem cell compartment and to enhance their expansion.