Method for ex-vivo expansion of hematopoietic cells

Patent Number: 6251383

This patent covers the use of an extract of the plant called Tinospora cordifolia for stimulation of hematopoietic stem cells.

Inventors: Upadhyay, Shakti N. (New Delhi, IN); Madan, Vikas (New Delhi, IN)

Assignee: National Institute of Immunology (New Delhi, IN)

Date of First Priority Issue: Tuesday April 20th, 1999

G-CSF mimetics

Patent Number: 6346531

This patent provides compositions of matter that are useful for stimulating the receptor for granulocyte colony stimulating factor. The fact that G-CSF was the first drug introduced that acted on the level of stem cells suggests that this is an important area for drug development. This patent may be useful not only for stimulation of neutrophil function, but also for increasing stem...

Inventors: Luengo, Juan I (Audubon, PA); Duffy, Kevin J (Norristown, PA)

Assignee: SmithKline Beecham Corporation (Philadelphia, PA)

Date of First Priority Issue: Saturday March 20th, 1999

Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction

Patent Number: 6790838

This patent teaches ways of improving the transfection of liver cells with genes in vivo. Transfection of liver cells is performed through the administration of the thyroid hormone T3, as well as keratinocyte growth factor. The transfection of liver cells may be performed not only for treatment of genetic disorders, but also for induction of islet...

Inventors: Alison, Malcolm R. (London, GB); Coutelle, Charles (London, GB); Forbes, Stuart J. (London, GB); Hodgson, Humphrey J. F. (London, GB); Sarosi, Ildiko (Newbury Park, CA); Themis, Michael (Oxfordshire, GB)

Assignee: Amgen, Inc. (Thousand Oaks, CA) Imperial College Innovations LTD (London, GB)

Date of First Priority Issue: Tuesday February 23rd, 1999

Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction

Patent Number: 6248725

This is an interesting patent that teaches the concurrent administration of the thyroid hormone T3, together with keratinocyte growth factor (KGF) can stimulate proliferation of endogenous hepatic stem cells.

Inventors: Alison, Malcom R. (London, GB); Coutelle, Charles (London, GB); Forbes, Stuart J. (Middlesex, GB); Hodgson, Humphrey J. F. (London, GB); Sarosi, Ildiko (Thousand Oaks, CA); Themis, Michael (Buckinghamshire, GB)

Assignee: Amgen, Inc. (Thousand Oaks, CA)

Date of First Priority Issue: Tuesday February 23rd, 1999

Proteins related to neuronal regeneration and uses thereof

Patent Number: 6783982

This patent teaches that neural stem cells can be expanded through the use of a novel protein called Neural Plakophilin Related Armadillo Protein (hNPRAP). Additionally the patent claims the induction of cellular extensions ushing hNPRAP.

Inventors: St. George-Hyslop, Peter H. (Toronto, CA); Fraser, Paul E. (Toronto, CA)

Assignee: The Governing Council of The University of Toronto (Toronto, CA)

Date of First Priority Issue: Friday February 12th, 1999

Propagation of human hepatocytes in non-human animals

Patent Number: 6995299

This patent teaches ways of growing human hepatocytes in xenogenic hosts. This patent would be useful for using animals as "bioincubators" in order to grow organs or cells for human use. Specifically the patent has two independent claims. The first covers a model of hepatitis C in which a mammal is injected with human hepatocytes when it is in the fetal stage, thus becoming...

Inventors: Wu, George Y. (Avon, CT); Wu, Catherine H. (Avon, CT)

Assignee: University of Connecticut (Farmington, CT)

Date of First Priority Issue: Thursday February 11th, 1999

Use of vascular endothelial growth factor to treat photoreceptor cells

Patent Number: 7,223,724

Macular degeneration and various other types of ocular pathology are usually associated with uncontrolled proliferation of blood vessels near the retina. The covering of nerves by new blood vessels usually causes dysfunction of the nerves and in some cases blindness. It is known that the compound VEGF is associated with pathological angiogenesis, and accordingly, the...

Inventors: Alderson; Ralph (Gaithersburg, MD), Melder; Robert (Boyds, MD), Roschke; Viktor (Rockville, MD), Ruben; Steven M. (Olney, MD), Rosen; Craig A. (Laytonsville, MD)

Assignee: Human Genome Sciences, Inc. (Rockville, MD)

Date of First Priority Issue: Monday February 8th, 1999

Method of producing undifferentiated hemopoietic stem cells using a stationary phase plug-flow bioreactor

Patent Number: 6911201

One of the limiting factors to clinical use of autologous hematopoietic stem cells, as well as cord blood cells, is the limited ways of expanding them. This patent addresses this issue by providing a novel system for such expansion that appears to be more "in vivo-like". Essentially, the patent has 2 independent claims covering: A method of expanding undifferentiated...

Inventors: Merchav, Shoshana (Haifa, IL); Meretzki, Shai (Nesher, IL)

Assignee: Technion Research & Development Foundation Ltd. (Haifa, IL)

Date of First Priority Issue: Thursday February 4th, 1999

Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair
Patent Number: 6890897

This patent teaches the novel use of melanoma inhibitory factor to induce stem cell differentiation into bone and cartilage. It may be used for in vitro generation of stem cells or for acceleration of in vivo healing. The independent claims of the patent are: A method for inducing chondro-/ostrogenic lineage and promoting of cartilage or bone formation in a person...
Inventors: Dony, Carola (Munchen, DE); Proetzel, Gabriele (Schwanfeld, DE); Leser-Reiff, Ulrike (Penzberg, DE)

Assignee: Scil Technology GmbH (Martinsried, DE)

Date of First Priority Issue: Thursday January 28th, 1999

Anti-transforming growth factor Beta (TGF-.beta.) treated stem cell composition and method
Patent Number: 6627191

This patent teaches the use of antibodies to TGF beta in order to stimulate hematopoietic stem cell renewal. Hematopoietic stem cells generation secrete autocrine TGF beta which inhibits their proliferation. This patent inhibits the inhibitor thus attaining stem cell expansion.

Inventors: Bartelmez, Stephen H. (Seattle, WA); Sitnicka, Ewa (Lund, SE); Ruscetti, Frank (New Market, MD)

Assignee: Seattle Biomedical Research Institute (Seattle, WA)

Date of First Priority Issue: Monday January 25th, 1999

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