Class: Expansion (390)
Compositions for controlling hair growth
Patent Number: 7,223,562This patent covers a novel protein called follicular papilla-1 (FP-1), that is selectively expressed in follicular papilla but not in dermal fibroblasts. The patent covers the FP-1 composition of matter, as well as vectors expressing it, cells expressing it, and specific sequences. FP-1 is essential for hair growth has demonstrated by siRNA and antibody inhibition experiments. Additionally...
Method for treatment of depression
Patent Number: 7,309,348The use of various types of energies to manipulate stem cells or to modulate the specific niche in which stem cells are placed is an exciting area of development. Photothera is a San Diego based company that has been clinically developing an area called "photoceuticals" for the past several years, primarily in relation to...
Composition and method for culturing potentially regenerative cells and functional tissue-organs in vitro
Patent Number: 6972195This patent teaches the composition of a culture media that is shown in the EXAMPLES section useful for growing: Human Intestinal Cells, Mouse Intestinal Mucosal Villi, Mouse Bone Marrow Tissue , Rat Nerve Tissue, Mouse Pancreatic Cells, Mouse Renal Cells, Human Hair Follicles, Rat Cardiomuscular Cells, Rat Thymocytes , and Rat Hepatocytes. The examples also show...
Cell culturing and storage systems, devices and methods
Patent Number: 7091035This invention is important for entities looking to expand various stem cells in vitro. The inventors noted that stem cells can differentiated into various types of other cells, and that a "dynamic" method of growing stem cells is relevant to what type of cells can be produced. The invention essentially covers ways of watching and manipulating stem cells and their progeny in culture as...
Cultured cells from pancreatic islets
Patent Number: 7,157,278The possibility of ex vivo expansion of islets has been a goal of cell therapy researchers for decades. This patent teaches methods of isolating beta precursor cells from pancreatic islets, expansion ex vivo through culture in serum-free growth factors, and the possible use for replacement therapy in diabetics. Identification of islet precursors is performed by assessment of nestin and pdx1...
Compounds and methods for increasing neurogenesis
Patent Number: 6969702This patent deals with administration of compounds, some which I believe are already in the clinic, for stimulation of neurogenesis in a patient suffering from a neurodegenerative condition. The patent has 2 independent claims, the first covers the administration of calcitonin, or exendin or analogues thereof that intracellular cAMP levels. The second independent claim covers administration...
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Methods for promoting wound healing
Patent Number: 7,189,746The stimulation of healing processes after injury involves a neurological component. The inventors of the patent clearly demonstrate through several prior art examples that wound repair requires innervation of the peripheral tissue, and that damage to the surrounding nerves results in inhibition of wound repair.
For example, the inventor describes a paper (Huang et al. Influence of... Human embryonic stem cells were classically grown on mouse feeder layers. Unfortunately these cells can not be clinically used since numerous adventitious viruses and infectious agents exist that theoretically can infect humans.
The current patent teaches the use of human foreskin fibroblasts as feeder layers for growing embryonic stem cells. Foreskin fibroblasts are conventionally... This patent covers a screening system for assaying small molecule libraries for telomerase stimulating activity. Specifically, the inventors have found that telomerase reverse transcriptase (TERT) activity can be modulated by agents that alter the binding interaction of the GC-Box 5 repressor site with a repressor protein (or protein complex including the same). Using this system the... This patent is useful for expansion and maintaining mesenchymal stem cells through the uniquely discovered property of cord blood serum to be able to substitute for other sources of serum such as fetal calf serum. The patent has 3 independent claims. The first is directed towards growing mesenchymal stem cells, and the second at third are directed towards isolating mesenchymal stem cells by...
Human foreskin fibroblasts for culturing ES cells
Patent Number: 7,267,981
Methods and compositions for modulating telomerase reverse transcriptase (TERT) expression
Patent Number: 7,279,328
Growth of human Mesenchymal Stem Cells (hMSC) using umbilical cord blood serum and the method for the preparation thereof
Patent Number: 7060494