Class: Expansion (410)
Serum-free basal and culture medium for hematopoietic and leukemia cells
Patent Number: 5397706This patent teaches the making of a serum free media for growth hematopoietic stem cells. Such a media is useful since the addition of fetal serum and especially fetal calf serum in culture medium for cell therapy is associated with regulatory hurdles.
Proliferation of hepatocyte precursors
Patent Number: 6146889Disclosed are culture conditions and compositions of matter that are useful for expansion of liver stem cells. This patent is useful not only for the generation of single cell hepatocytes, but may be used with other scaffold patents in order to generate artificial liver lobes.
Hemopoietic stem cell multiplier
Patent Number: 6221359This patent covers the use of hepatocyte growth factor (and various combinations) for the stimulation of hematopoietic stem cells.
Methods of proliferating undifferentiated neural cells
Patent Number: 7,115,418This patent teaches ways of expanding neural stem cells without inducing loss of replicative ability. Specifically, this involves culture with one or more growth factors selected from a group comprising of EGF, amphiregulin, FGF-1, FGF-2 and TGF-beta.
Growth factor-induced proliferation of neural precursor cells in vivo
Patent Number: 5980885This patent teaches the in vivo expansion of neural stem cells through administration of fibroblast growth factor in combination with an agent selected from the group comprising of: EGF, TGF, and amphiregulin. This patent is useful for the treatment of degenerative nervous system diseases alone, or in combination with exogenously administered stem cells.
In vitro growth and proliferation of multipotent neural stem cells and their progeny
Patent Number: 5851832This patent covers a type of neural stem cell that can differentiate into neurons and neuron supporting cells. This patent also teaches ways of expanding and differentiating the neural stem cells.
In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
Patent Number: 5750376This patent covers neural stem cells of a specific phenotype and their use for delivery of gene products into an area of need.
Method for culturing T precursor cells under conditions of high oxygen concentration
Patent Number: 5476780The stem cells that generate T cells originate in the bone marrow and differentiate in the thymus. This patent teaches that T cell precursors can be expanded in high oxygen conditions in a thymic-like microenvironment. This patent is very interesting not only from the point of view of generating T cells for immune stimulation, but also because theoretically it can be applied to the generation...
Method for improving autologous transplantation
Patent Number: 5199942Anyone performing autologous hematopoietic stem cell transplants should watch out for this patent !! This patent teaches essentially autologous transplantation with ex vivo expansion of stem cells. Numerous companies and scientists are doing or have done clinical investigations which potentially infringe on this patent.
Expansion of human hematopoietic progenitor cells in a liquid medium
Patent Number: 5744361This patent provide tissue culture reagents for the expansion of hematopoietic stem cells.