Class: Expansion (410)
Expansion of human hematopoietic progenitor cells in a liquid medium
Patent Number: 5409825This patent uses mast cell growth factor as an additive to tissue culture media in order to generate a liquid composition that is useful for expansion of hematopoietic stem cells. The ability of this media to expand other types of stem cells should be assessed.
Methods of culturing and modulating the growth of hair follicular stem cells
Patent Number: 5556783This patent covers methods of expanding stem cells derived from the hair follicle. One of the methods of expanding hair follicle stem cells is through growing then on 3T3 fibroblasts. Hair stem cells are somewhat similar to mesenchymal stem cells and may be useful for a wide variety of applications in addition to hair replacement.
Morphogen-enhanced survival and repair of neural cells
Patent Number: 6495513This patent provides certain morphogen proteins that are capable of regenerating neural stem cells, as well as protecting neurons from apoptosis or other types of cell death. The claims cover specific polypeptides for neurite extension, as well as for repairing the gap between neurons.
Hair growth regulating composition comprising epithelium cell supernatant-derived growth factor
Patent Number: 5130142This patent teaches the production of a chemical composition useful for growing hair in bald people. The composition is made from media conditioned by growing epithelial cells. The composition is mitogenic to dermal papilla cells and 3T3 fibroblasts but not to epidermal cells. The molecular weight of the active ingredient is > 3 kDa.
Uteroferrin and rose proteins for stimulating hematopoietic cells
Patent Number: 5258367This patent teaches that uteroferrin (placental Type V acid phosphatase) is a stimulator of hematopoietic stem cells. Uteroferrin is made during pregnancy and is associated with iron transport. The use of uteroferrin for hematopoiesis may be a potent new way of approaching the problem of neutropenia.
Stimulation, production, culturing and transplantation of stem cells by fibroblast growth factors
Patent Number: 5817773This patent teaches that members of the FGF family are useful for expansion of hematopoietic stem cells. This is interesting since FGF-2 was actually used in the clinic for treatment of stroke. Although results were impressive in small subsets of patients, the adverse effects of systemic administration of this protein stopped its clinical...
In vitro propagation of embryonic stem cells
Patent Number: 7,186,883Murine embryonic stem cell lines have revolutionized molecular biology by allowing the generation of transgenic and knockout mice. This technology allows for in vivo understanding of specific genes through either inducing over expression or complete silencing in a live animal. This patent covers methods of generating murine embryonic stem cells.
Methods and device for culturing human hematopoietic cells and their precursors
Patent Number: 5635387This patent provide conditions and systems for the ex vivo expansion of hematopoietic stem cells. Specific cell concentrations, growth factors, and vessels are provided. This patent is useful for expansion of cells either in the autologous situation, or in situations where an allogeneic source is not sufficient, such as in cord blood transplants.
Methods for promoting functional regeneration of mammalian muscle by administering leukaemia inhibitor factor
Patent Number: 6093390This patent teaches that LIF may be used alone, or in combination with neurotrophic factors for the stimulation of neurogenesis and muscle innervation. This patent may be useful for combining with exogenous stem cell sources such as cord blood. Additionally, the patent may be used for treating patients with multiple sclerosis.
Satellite cell proliferation in adult skeletal muscle
Patent Number: 5466676This patent teaches methods of transfecting various stem cells with therapeutic or marker genes. Particularly, muscle stem cells, called satellite cells are discussed as target cells suitable for transfection.