Class: Expansion (410)
Hepes based basal nutrient medium for the isolation and culturing of stem cells
Patent Number: 6162643This is a composition of matter patent on a tissue culture medium that is useful for the growth of various stem cells.
Process and media for the growth of human epithelia
Patent Number: 5834312This patent covers a liquid composition that is useful for the growth of epithelial cells and various stem cells that differentiate along the epithelial lineages. Relevant types of cells generated by this culture could be corneal epithelial or gingival cells.
Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
Patent Number: 5612211This patent covers the expansion of hematopoietic stem cells, both in vitro and in vivo with fibroblast growth factors. This patent is important not only for stimulation of post-ablation hematopoiesis, but can also be used to cover angiogenesis stimulation by fibroblast growth factors since angiogenesis involves hematopoietic stem cells, at least in some embodiments.
Method of stimulating bone marrow regeneration
Patent Number: 5888965This patent teaches how to enhance hematopoiesis using hepatocyte growth factor alone or in combination with other cytokines.
Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines
Patent Number: 5362716This patent covers stimulation of hematopoietic stem cells by administration of hepatocyte growth factor with either IL-3 or GM-CSF. Hepatocyte growth factor has been used clinically in a variety of situations including to stimulate angiogenesis. It may be interesting, in light of the claimed pro-hematopoietic stem cell activity of hepatocyte growth factor, to try using this cytokine...
Proliferative action of leukaemia inhibitory factor on satellite cells
Patent Number: 5435999Satellite cells are muscle stem cells. This patent teaches that LIF either alone, or together with TGF-beta, EGF, or FGF, is capable of stimulating proliferation of muscle satellite cells. This technology is useful not only for stimulating proliferation of endogenous satellite cells after...
Method of using IL-11 for treating deficiencies in hematopoietic progenitor or stem cells
Patent Number: 6066317This patent teaches that interleukin 11 can be administered into patients for stimulation of hematopoietic activity. Interleukin 11 is known to upregulate platelet production but not as potently as TPO.
SCL: a hematopoietic growth and differentiation factor
Patent Number: 5214133This patent is for a transcription factor associated with stem cell activity. The factor is a basic helix-loop-helix transcription factor called SCL/Tal1. It is expressed in cells that possess hematopoietic stem cell activity and controls numerous genes associated with stem cell functions. Modification of activity of this transcription factor may be used...
Method for increasing hematopoietic progenitor cells by stem cell factor
Patent Number: 6967029This patent has 2 independent claims both covering the use of stem cell factor for stimulation of hematopoiesis. The first independent claim covers its use in vivo, whereas the second covers its use ex vivo.
Stem cell factor compositions
Patent Number: 6841147This is a composition of matter patent on the kit-ligand, otherwise known as stem cell factor. Stem cell factor is involved in regulation of a variety of stem cells in addition to hematopoietic stem cells. This patent is particularly important for when novel methods of inducing stem cell differentation in vivo are discovered and stem cell factor may be added to these methods to either...