Class: Expansion (410)
Stem cell factor and compositions
Patent Number: 6207802This is one of the composition of matter patents on the stem cell stimulatory cytokine called "stem cell factor". Since the receptor for this cytokine, c-kit, is present on numerous other types of stem cells (ie cardiac, muscle, kidney stem cells), it is of interest whether this cytokine can also be of use in expanding non-hematopoietic stem cells.
Stem cell factor
Patent Number: 6204363This patent covers the composition of matter for a stem cell expansion protein named "stem cell factor", this is the ligand for c-kit.
Method for inhibiting growth of stem cells
Patent Number: 5674841Disclosed is a peptide that inhibits stem cell proliferation...it doesnt give a name for the peptide..
Method for stimulating production of bone marrow cell growth factors using dithiocarbamates
Patent Number: 5169765This patent teaches that dithiocarbamate and its analogues have the ability to stimulate bone marrow production of hematopoietic growth factors. Dithiocarbamate may be used according to the invention for stimulation of hematopoietic cells to produce growth factors, and subsequently the dithiocarbamate may be taken off the cells. While this patent seems like a really interesting method of...
Hemoregulatory peptides
Patent Number: 5620957This patent provides novel compositions of matter for stimulation of hematopoietic stem cells. This patent is useful for post chemotherapy and post radiation therapy stimulation of blood cell production. It may be useful for stimulation of other stem cells as well, including for stimulation of endothelial precursors and angiogenesis.
Method for protecting bone marrow against chemotherapeutic drugs using transforming growth factor beta 1
Patent Number: 5278145TGF-beta is an inhibitor of hematopoietic stem cell proliferation. It is known that autologous TGF-b is involved in keeping stem cells in a quiescent G0 state. This patent teaches the systemic administration of TGF-b before administration of a chemotherapeutic drug so as to protect the stem cells from damage.
Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
Patent Number: 6326198This patent provides systems for expanding hematopoietic stem cells, but culturing of these cells on stromal cells which secrete IL-6, and/or GM-CSF. It is important for the stromal cells to be secreting these compounds since stromal cells possess a wide variety of hematopoietic stimulatory signals, some known and others unknown. The synergy of the stromal signals with IL-6 and/or GM-CSF is...
Devices for maintaining and growing human stem and/or hematopoietics cells
Patent Number: 5888807This patent provides bioreactors and specialized culture vessels that are useful for the growth and expansion of human hematopoietic stem cells.
Methods and compositions for the ex vivo replication of human hematopoietic stem cells
Patent Number: 5670351This patent covers methods of expanding human hematopoietic stem cells through ex vivo transfection with various genes. Specific culture conditions are also provided. This patent can be used for post myeloablative reconsitution, but also, theoretically, for stimulation of angiogenesis by administration of the bone marrow stem cells into ischemia areas.
Device for maintaining and growing human stem and/or hematopoietics cells
Patent Number: 5459069This patent provides tissue culture devices that can be used for expansion of hematopoietic stem cells. The tissue culture devices allow for a culture of stem cells to be performed so that the stromal cells that provide various factors to the stem cells do not come into direct contact with the stem cells.