Class: Expansion (401)
Hemolymphopoietic growth factors, process for purifying and producing hemolymphopoietic growth factors and pharmaceutical compositions made therefrom
Patent Number: 5264418This patent claims a hematopoietic stem cell growth factor called HLGF. This factor seems to synergize with other stem cell stimulator factors such as G-CSF, GM-CSF, and IL-3. The modern identify of this factor will be of interest since it may be developed into a therapeutic.
Human pluripotent granulocyte colony-stimulating factor
Patent Number: 5580755This patent covers a growth factor called human pluripotent granulocyte colony stimulating factor. Since names of growth factors have been standardized, it is difficult to tell which modern-day cytokine this is referring to. In any case, this growth factor is an expander of hematopoietic stem cells, and is useful for treatment of patients whose hematopoietic system has been minimized either...
Human pluripotent hematopoietic colony stimulating factor, method of production and use
Patent Number: 6838549This is a patent for a hematopoietic stimulatory cytokine that the inventors named pluripoietin alpha. This cytokine is described in several papers including (Gabrilove et al. Pluripoietin : A Second Human Hematopoietic Colony-Stimulating Factor Produced by the Human Bladder Carcinoma Cell Line 5637, PNAS | April 15, 1986 | vol. 83 | no. 8 | 2478-2482). This...
Human pluripotent hematopoietic colony stimulating factor, method of use
Patent Number: 6419918This patent covers the pluripotent colony stimulating factor, a type of cytokine that is not really described in terms of modern nomenclature in this patent. The use of such stem cell stimulatory cytokines that come from the hematopoietic system should be explored for other types of stem cells...this is especially since there is so much similarity between stem cells of various tissues not...
Human pluripotent hematopoietic colony stimulating factor and cell line producing same
Patent Number: 6114166This patent covers a cytokine that stimulates proliferation of hematopoietic stem cells which give rise to all hematopoietic lineages.
Pharmacological preparations comprising human pluripotent hematopoietic colony stimulating factor
Patent Number: 5670146This patent covers the various formulations of human p-CSF. It also covers the factor's use for stimulation of hematopoiesis. I wonder what the modern name for p-CSF is?
DNA encoding GM-CSF and a method of producing GM-CSF protein
Patent Number: 5908763This patent covers composition of matter for the hematopoietic cytokine granulocyte monocyte colony stimulating factor.
Stem cell proliferation factor
Patent Number: 5981708This patent covers a cytokine whose modern name is not known from reading the patent. The cytokine is capable of stimulating expansion of CD34+ human hemapoietic stem cells.
Method for in vitro culture of mammalian cells
Patent Number: 5223428This patent teaches methods of culturing and expanding cells, including stem cells, through a unique culture system that uses hollow fiber technology. Since tissue culture is usually performed under static conditions and very derived from the in vivo situation, numerous failures to expand stem cells can be explained. The culture system of this invention seeks to provide a more in vivo like...
Enhanced growth medium and method for culturing human mammary epithelial cells
Patent Number: 4423145This patent covers ways of growing mammary epithelial tissue in vitro. It teaches that such cells can be grown through dissociating stromal cells using enzymez and mechanical means so as to obtain a population of clumps of epithelial cells. The epithelial cells are then grown in a conditioned media that is either conditioned by human fetal intestine epithelial cells or human bladder...