Class: Expansion (390)

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Device and a process for expansion of haemopoeitic stem cells for therapeutic use

Patent Number: 7,179,643

The problem with cord blood as a source of stem cells is that not many cells can be harvested. Although enough cells are usually present to treat a pediatric patient, in cases of adults, expansion of stem cells from the cord blood is desirable. The current patent provides a portable bioreactor for expansion of cord blod stem cells. Essentially, the invention is designed so as to be able to...

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Propagation and/or derivation of embryonic stem cells

Patent Number: 7,371,573

This patent covers methods of growing embryonic stem cells outside of the body using novel tissue culture media and media additives. 

Specifically, it covers the use of compounds that inhibit MEK-1 and/or MEK-2, as well as compounds that activate gp130 for use in stem cell propagation.  This claim conceptually blocks anyone from using compounds known and unknown that modulate...

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Method and device stimulating the activity of hair follicles

Patent Number: 6666878

This patent provides various frequencies of light, and ways of administering light so as to stimulate proliferation and differentiation of the stem cell that is responsible for hair growth. It will be interesting to see if these methods and devices provided can also stimulate other types of stem cells. The use of light may also be beneficial for stimulating proliferation of cancer stem...

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Numb protein expression inhibitors by Musashi

Patent Number: 7,264,793

Musashi is a protein found on stem cells of the neural lineage. This patent covers the administration of Musashi to increase proliferation of neural stem cells. The patent also covers the use of Musashi to inhibit the repressor of Notch signalling Numb and thereby sensitize neural stem cells to proliferative/expansionive signals.

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Method for stimulating hair follicle cell proliferation

Patent Number: 7,335,641

The current patent covers ways of induce proliferation of hair follicle cells through administration of a specific protein or variants of it. The protein is called "hair follicle growth factor" or "HFGF". HFGF is considered to be an allelic form of keratinocyte growth factor-2 (KGF-2) wherein HFGF has a glutamic acid residue (Glu) at...

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Hair follicle growth factor proteins

Patent Number: 7094569

This patent is useful for induction of hair growth through use of hair follicle growth factor (HFGF) proteins. Essentially, the HFGF proteins described in the application appear to be allelic variants of keratinocyte growth factor-2 (also known as FGF-10). There are both composition of matter, use, and delivery claims issued. One of the...

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Use of osteopontin for the treatment and/or prevention of neurologic diseases

Patent Number: 7,217,687

Osteopontin, is a protein also called cytokine Eta-1, which contains Arg-Gly-Asp-Ser (RGDS) cell-binding sequences. Osteopontin is associated with cancer metastasis, as well as inflammatory immune cell migration, it interacts with alpha(v)beta1, alpha(v)beta3 and alpha(v)beta5 integrins and CD44 receptors. The current patent covers the use of osteopontin and...

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Treatment for wounds

Patent Number: 7,262,174

The use of epithelial cells (such as fibroblasts) transfected with telomerase for acceleration of wound healing is covered by this patent. This invention is conceptually attractive, however the possible effects of telomerase transfection in terms of immortalization of cells showed be consided. Since wounds already express inflammatory mediators such as free radicals (which damage Inventors: Jiang; Xu-Rong (Mountain View, CA), Chiu; Choy-Pik (Cupertino, CA), Harley; Calvin B. (Palo Alto, CA)

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