Class: Expansion (395)
Methods of identifying compounds for regulating muscle mass or function using vasoactive intestinal peptide receptors
Patent Number: 6750194This patent covers expansion of muscle mass through the use of vasoactive intestinal peptide receptors (VPAC)agonists. The activity of such agonists on stem cells are only beginning to be identified, and I am sure this area is ripe for expansion...for example, what do such agonists do on neural stem cells?
Hematopoietic growth factor inducible neurokinin-1 gene
Patent Number: 6939955This is a composition of matter patent for a receptor that seems to be involved in hematopoietic stem cell expansion. The invention discloses a novel gene, HGFIN, which encodes a protein receptor that is involved in the regulation of hematopoietic proliferation and differentiation, and may act as a negative regulator of the Id2 protein. The invention has 2...
Method of inducing new bone growth in porous bone sites
Patent Number: 6599520This patent provides matrices that are useful for treatment of bone disorders. The matrices may be seeded with stem cells to accelerate regeneration of bone.
Nuclear reprogramming using IWSI and related chromatin remodeling ATPases
Patent Number: 7053264This patent is useful for parties seeking to perform cloning or generate stem cells through cloning. During nuclear transfer mediated cloning, one of the difficulties is that the donor nucleus has DNA packed tightly into chromatin. During usual nuclear transfer it is the role of the recipient oocyte to unravel the DNA and to perform the...
Serum free cultivation of primate embryonic stem cells
Patent Number: 7005252The use of serum in stem cell cultures impedes clinical translation since serum has batch to batch variability, as well as possibility of eliciting allergic responses, especially when fetal calf serum is used. The invention teaches how to grow embryonic stem cells without serum. Essentially the claims of the invention all cover compositions of albumin, amino acids, vitamins, minerals, at least...
Methods and compositions for modulating telomerase reverse transcriptase (TERT) expression
Patent Number: 6686159Telomerase induces cellular escape from sensence and is important for stem cell activity, as well as for cancer to becoming immortal. In this patent agents are identified that suppress the suppressor of telomerase, therapy allowing various types of cells to express telomerase and thereby escape senescence.
Histone deacetylase, and uses therefor
Patent Number: 6673587This is a composition of matter patent on several proteins that function as histone deacetylases. Histone deacetylases act at an epigenetic level through modifying histones and controlling gene transcription. Manipulation of histone deacetylase activity can be used to change cellular fate.
Retro-inverso peptides derived from leukemia inhibitory factor
Patent Number: 7,109,168Leukemia inhibitory factor (LIF) is classically known for its ability to maintain murine embryonic stem cells in an undifferentiated state. Various types of non-embryonic stem cells also respond to LIF. For example, LIF supplementation to human fetal cortical cells increases telomerase activity and endows increased self-renewal potential...
Transforming growth factor beta (TGF-.beta.) blocking agent-treated stem cell composition and method
Patent Number: 6841542This patent claims ex vivo inhibition of TGF beta in hematopoietic stem cells in order to increase speed of engraftment post recipient marrow ablation. Since TGF beta is an endogenous inhibitor of stem cell proliferation, the inhibition of the inhibitor should lead to enhanced proliferation. The technology described in this patent...
Culturing pancreatic stem cells having a specified, intermediate stage of development
Patent Number: 6759039This patent covers methods of culturing and expanding pancreatic stem cells. These cells may be used for the treatment of diabetes through encapsulation or administration into the liver such as thought by the Edmonton Protocol.