Class: Extraction/Preservation (153)
In vitro-derived genetically altered human neutrophil precursor cells and methods for administering the same
Patent Number: 6146623This patent covers genetic transfection of stem cells that give rise to neutrophils. Transfection of this cell population may be performed to enhance their ability to proliferate, or may be performed to endow them with increased antibacterial activities.
Methods of isolating hepatic progenitors
Patent Number: 7109028This patent is useful for parties seeking to purify hepatic progenitor cells, or hepatic stem cells. The patent has one independent claim that essentially teaches how to "negatively deplete" a single cell suspension of hepatocytes for all cells except hepatic stem cells. The patent also claims the marker OC3 as expressed on hepatic stem cells. A...
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Multipotent neural stem cell cDNA libraries
Patent Number: 6399369This patent provides the genes that are expressed in various neuronal cells and stem cells. These genes are useful for identifying markers of stem cells that can be used for their extraction and isolation. Additionally, knowledge of these genes may enable drug discovery and target identification for ways of expanding and/or differentiating neural stem cells.
Monoclonal antibodies for human mesenchymal stem cells
Patent Number: 6087113As part of Osiris's territorial stake on the mesenchymal stem cell area, this patent covers antibodies that are publically available from ATCC, that specifically recognize mesenchymal stem cells.
Methods of purifying hematopoietic cells using an antibody to a stem cell factor receptor
Patent Number: 5922847This patent teaches ways of purifying hematopoietic stem cells based on their expression of the marker c-kit. This marker is the receptor for the cytokine stem cell factor that was developed by Amgen.
Method for isolating stem cells expressing flk-1 receptors
Patent Number: 5912133This patent teaches that cells expressing flk-1 on their surface may be stem cells. It specifically provides methods of using flk-1, alone, or in combination with other markers for the purification of stem cells.
Purification and manipulation of bone marrow and blood cells on the basis of P-glycoprotein expression
Patent Number: 5464753This patent teaches that stem cells have an active efflux mechanism similar to the way that cancer cells have an efflux mechanism that makes them drug resistant. The only question about this patent is whether it also covers stem cells that are already identified using other markers. For example, it is very likely that the stem cells, at least hematopoietic stem cells that possess the efflux...
Method for isolating cells expressing flk-2
Patent Number: 6960446fetal liver kinase 2 (flk-2) is expressed on numerous types of stem cells. This patent covers isolation of cells expressing this marker using either a monoclonal or polyclonal antibody. The patent has 1 independent claim which essentially covers the subject matter previously mentioned. The importance of flk-2 on hematopoietic stem cells was published by the author (Matthews W, et al. A...
Monoclonal antibodies for human mesenchymal stem cells
Patent Number: 5837539This patent covers the use of specific antibodies for the isolation and detection of mesenchymal stem cells. The antibodies are deposited at ATCC and can be purchased publically.
Continuous centrifugation process for the separation of biological components from heterogeneous cell populations
Patent Number: 5641622This patent covers the use of continuous flow centrifuges and various systems for purification of homogeneous cells from a heterogeneous population. This patent may be useful for purifying stem cells from blood based on weight and other physical characteristics.