Methods of purifying stem cells, as well as progenitor cell populations are well known in the art. Unfortunately, some of these methods have certain limitations, and as a result, there is always a great need to identify new ways of sometimes doing the same thing. For example, it is known that CD34 is a useful marker for hematopoietic stem cells. However, since the...
The quest for a stem cell therapy for diabetes has led to the evaluation of numerous cellular sources ranging from embryonic stem cells, to bone marrow derived stem cells, to mesenchymal stem cells. One interesting method of expanding insulin producing cells is through extraction of pancreatic...
This patent covers a medical device that is useful for purifying hematopoietic stem cells. The medical device selects stem cells but not contaminating cancer cells, and is therefore useful for treatment of cancer patients by purifying autologous stem cells before high dose chemotherapy so that the stem cells can be re-introduced in order to accelerate reconstitution of hematopoiesis.
The patent covers generation of angiogenic cells from embryonic stem cells using a novel method. Specifically the patent covers a way to generate such angiogenic cells by: 1) culturing individual ES cells in an unaggregated state under conditions that induce differentiation into vasculagenic progenitors (the claim is not limited by what those conditions are!) 2) isolating cells...
CD-117, otherwise known as c-kit, is the receptor for stem cell factor, a cytokine involved in stimulating a variety of stem cells to cycle. Although c-kit was originally described on hematopoietic stem cells, this receptor has recently been found on numerous stem cell types ranging from liver oval cells to pancreatic duct stem cells. Additionally, c-kit has been found on tumor stem...
Adipose tissue is known to contain a variety of different cellular populations. For example, Medistem Inc (mdsm.ob) reported presence of immune suppressive T regulatory cells in adipose tissue that could potentially be useful for inhibiting autoimmunity.
Another type of cell found in adipose tissue is endothelial... Teeth are known to contain various cellular populations in the pulp, including stem cells. The idea of banking tooth stem cells is limited by the ease of extraction. This patent discloses various apparatus' that are easily used for the extraction of tooth stem cells. Although the WARF/Geron patents have attracted much attention in recent history, many forget about the large embryonic stem cell patent portfolios that are being issued to institutions in countries such as Israel and India. The current patent, issued to the Indian stem cell giant Reliance, covers a method of generating embryonic stem cells that is significantly... This patent teaches how to generate sperm in vitro through the use of sertoli cells and undifferentiated diploid germ cells. It is useful not only for infertility applications, but also for various veterinary purposes. This patent teaches ways of identifying pancreatic stem cells by assessing expression of the gene which encodes pancreatic progenitor-1.
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Stem cell and dental pulp harvesting method and apparatus
Patent Number: 6767740
Isolation of inner cell mass for the establishment of human embryonic stem cell (hESC) lines
Patent Number: 7,294,508
In vitro production of haploid germ cells
Patent Number: 6872569
Pancreatic progenitor 1 gene and its uses
Patent Number: 6541251