Class: Extraction/Preservation (153)
Lineage specific cells and progenitor cells
Patent Number: 6929948This patent teaches ways of extracting cells with a neural phenotype from a population of stem cells that are differentiated along the neural lineage through selecting cells that express a marker under control of a promoter which is active only in neural cells. Specifically, the patent claims the use the Sox gene promoter. One way to use this patent would be to insert GFP... When growing neural stem cell cultures, at a certain point in culture they need to be passaged. According to the background in the patent, before the invention, scientists would dissociate neurospheres by mechanical means, which as one could expect causes a loss in cell viability. This patent covers the use of collagenase in dissociating neurospheres when passaging them. This patent is... This patent teaches that tissue samples, or neurospheres, may be dissociated with collagenase instead of mechanical means, in order to maintain viability of the stem cell component. StemCells Inc is one of the few companies that has actually entered clinical trials. In this patent the extraction of specific neuronal stem cells is disclosed. Cells that bind to the antibodies 5E12 and/or AC133 derived from brain sources are identified as neuronal stem cells capable of inducing production of neurospheres. These cells have also demonstrated ability... This patent covers a medical device that is useful for the concentration of stem cells, especially hematopoietic stem cells, from peripheral blood and other fluids. This patent provides ways of extracting stem cells based on their expression of aldehyde dehydrogenase. This patent is in clinical trials by the company Aldegen. This patent is directed primarily at muscle stem cells and methods of expanding and isolating them by culturing at low oxygen tension. It seems like muscle stem cells are similar to hematopoietic and neuronal stem cells in the fact that they prefer conditions of low oxygen tension. This patent teaches a new way of cloning, including for the generation of embryonic stem cells, by selecting oocytes at a specific cell stage called telophase. It is not good enough to encapsulate stem cells for therapeutic use, since the stem cells will have to be transported to the hospital or institution where they are needed. This patent covers methods of cryopreserving cells that have been encapsulated so that they may be shipped to the region of need. This patent covers VCAM positive bone marrow stromal cells. These are the cells that support hematopoietic stem cell proliferation. Do mesenchymal stem cells have VCAM on them??
Use of collagenase in the preparation of neural stem cell cultures
Patent Number: 7049141
Use of collagenase in the preparation of neural stem cell cultures
Patent Number: 6238922
Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
Patent Number: 6468794
Blood separation system particularly for concentrating hematopoietic stem cells
Patent Number: 6733433
Method of isolating stem cells
Patent Number: 6627759
Methods for isolation and activation of, and control of differentiation from, stem and progenitor cells
Patent Number: 6589728
Methods for cloning mammals using telophase oocytes
Patent Number: 6781030
Methods and compositions for cryopreservation of cells and tissues
Patent Number: 6176089
Methods of isolating and detecting bone marrow stromal cells with VCAM-1-specific antibodies
Patent Number: 5827670