Class: Mobilization (25)
Growth factor therapy mobilization of stem cells into the peripheral blood
Patent Number: 7,288,521This patent covers a new way of mobilizing stem cells. Stem cell mobilization is usually performed on the donor of a hematopoietic graft so that instead of needing to puncture the donor bones to get bone marrow, the stem cells are "forced" into circulation by administration of a growth factor. Conventionally mobilization of stem cells is performed by systemic administration of G-CSF. In...
Purposeful movement of human migratory cells away from an agent source
Patent Number: 7,141,363Chemotactic gradients are critically important in stem cell function. This is demonstrated not only in the fact that the bone marrow constitutively secretes SDF-1 in order to allow systemically infused stem cells to home back to the bone marrow, but also in regenerative medicine where injured tissue releases chemokines to attract endogenous stem cells. The...
Methods for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood in a patient in need of chemotherapy
Patent Number: 6566335This patent teaches ways of mobilizing hematopoietic stem cells by administration of angiotensin I and/or II and/or analogues thereof.
Molecules that home to various selected organs or tissues
Patent Number: 6610651This patent covers peptides that specifically home to the lung. This patent is useful for delivering compounds that activate pulmonary stem cells to the lung. Since injected stem cells generally go to the lung, the administration of stem cell factors targeted to the lung using these peptides in combination with exogenous stem cells may be a new therapeutic approach.
Combination of G-CSF with a chemotherapeutic agent for stem cell mobilization
Patent Number: 6162427This patent teaches that a more potent stimulation of hematopoietic stem cell mobilization can be achieved by combining G-CSF with cyclophosphamide, as opposed to administration of either alone.
Method of mobilizing stem cells with chemokine .beta.-8
Patent Number: 6713052This patent teaches ways of mobilizing hematopoietic stem cells using the chemokine know as beta-8. Mobilization may be performed for harvesting of stem cells from peripheral blood by leukopheresis, or it may be performed for the purposes of expanding the number of stem cells in circulation when there is a wound in the body that is attracting stem cells. Such a wound could be the lesion of...
Mobilization of peripheral blood precursor cells by .beta.(1,3)-glucan
Patent Number: 6117850This patent teaches how to mobilize stem cells through administration of beta glucan and various derivatives of it. The use of other immune stimulants and TLR agonists should be evaluated for mobilization in future.
Stem cell immobilization
Patent Number: 5912177This patent covers methods of "grabbing" stem cells by virtue of a fibrin matrix together with RGD binding motifs. The attachment of stem cells to various structures may be useful as a means of harvesting stem cells.
Increase in hematopoietic progenitor cells in peripheral blood by transforming growth factor .beta.
Patent Number: 5674843This patent teaches that the stem cell inhibitory compound TGF-beta may be administered for the purpose of mobilization.
Release and mobilization of haematopoietic cells
Patent Number: 5925568This patent teaches that the chemokines MIP-1 alpha/LD78 are capable of causing the mobilization of stem cells from the bone marrow. This patent is useful for increasing the number of circulating stem cells from a donor so that peripheral blood may be harvested for stem cells for transplantation. Additionally, mobilization may be performed in a patient with a...