Class: Type (181)

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Mesenchymal precursor cell

Patent Number: 7,399,632

Mesenchymal stem cell therapy is rapidly becoming a clinical reality.  The beauty of this cell population is that it can be used in an "off the shelf" manner and does not appear to have many safety issues.  Mesenchymal stem cells from the bone marrow have been patented by Osiris, whereas cells similar to mesenchymal stem cells have been...

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Pluripotent adult stem cells

Patent Number: 7,259,011

This patent covers a stem cell that is positive for expression of CD13, CD34, CD56 and CD117, negative for CD10. Dependent claims further cover the phenotype of CD2, CD5, CD14, CD19, CD33, CD45, and DRII negative, CD13,CD34, CD56, CD90, CD117...

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Primitive and proximal hepatic stem cells

Patent Number: 7,413,897

The liver is one of the organs that has been demonstrated to respond to stem cell therapy both in animal models and in clinical trials.  It is known that the liver has endogenous stem cells, but also that bone marrow stem cells can differentiate into liver cells.  In fact, it is published that...

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Insulin-secreting immortalized liver cell line modified by glucose sensitivity

Patent Number: 7,312,077

It has previously been demonstrated that rat hepatic cells can be coaxed into producing insulin by isolating the hepatic cells from an animal that was first primed with a hepatoxin, and subsequently exposing the isolated hepatic cells to high glucose concentrations. In the current patent a hepatic cell line that has been...

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Efficient nuclear transfer with primordial gametes

Patent Number: 7,351,876

This patent covers a new method of cloning cows.  Specifically, the patent teaches a method of making a cow blastocyst by

- extracting a primordial gamete cell population from the cow fetus
- using the nucleus of the primordial gamete cell as a nuclear donor for an enucleated oocyte
- and activating the combination of the primordial gamete nucleus with the recipient...

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Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations

Patent Number: 7,381,561

This patent covers methods of isolating neural stem cells using antibodies that bind CD49f. The first independent claim is very broad in that it is not restricted to originating material of adult or embryonic origin but simply covers a method of purifying a population by selecting for cells that initiate neurospheres in culture and express CD49f. CD49f is found on other types of stem cells as...

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Somatic pluripotent cells

Patent Number: 7,422,736

Numerous patents exist on various types of stem cells.  For example, Osiris has overarching patents on any cell that expresses the mesenchymal stem cell markers SH2, SH3, or SH4.  An example of which is US patent # 5,486,359, in which the broadest claim covers "An isolated, homogeneous population of human mesenchymal stem cells which can...

Assignee: Food Industry Research and Development Institute (TW)

Date of First Priority Issue: Wednesday June 26th, 2002

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Meningeal-derived stem cells

Patent Number: 7,410,797

The current patent covers a type of multipotent stem cell derived from the meninges.  This is the three layered membrane that surrounds the cerebrospinal fluid and central nervous system.  The inventors have demonstrated that cells isolated from this membrane, regardless of whether they are from the dura mater, pia mater, or arachnoid mater, can be substantially expanded in vitro...

Inventors: Ogle; Roy C. (Earlysville, VA), Tholpady; Sunil (Charlottesville, VA)

Assignee: Not Stated

Date of First Priority Issue: Tuesday June 11th, 2002

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Dedifferentiated, programmable stem cells of monocytic origin, and their production and use

Patent Number: 7,138,275

This patent is highly interesting in that the inventors claim to have devised a simple and easy to implement methodology for generation of autologous stem cells. Essentially, the invention teaches that culturing of peripheral blood monocytes in the presence of IL-3 and M-CSF for approximately 6 days, somehow induces a program of de-differentiation in the monocytes to endow them with stem...

Inventors: Kremer; Bernd Karl Friedrich (Kiel, DE), Fandrich; Fred (Kiel, DE), Ruhnke; Maren ne (Kiel, DE)

Assignee: Blasticon Biotechnologische Forschung GmbH (Keil, DE)

Date of First Priority Issue: Thursday March 28th, 2002 8 Comments

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Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells

Patent Number: 7,311,905

Stem cell populations are known from the cord blood as well as the placental matrix. In the current patent a stem cell population from the placenta is covered that possesses markers of adult stem cells as well as embryonic stem cells. For example, the first claim covers...

Inventors: Hariri; Robert J. (Florham Park, NJ)

Assignee: Anthrogenesis Corporation (Summit, NJ)

Date of First Priority Issue: Wednesday February 13th, 2002 2 Comments

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