Class: Type (183)
Patent Number: 5869463
This patent covers a type of stem cell that is isolated from fetal brain that is useful for the treatment of neurodegenerative disease.
Inventors: Major, Eugene O. (Oakton, VA); Tornatore, Carlo S. (University Park, MD)
Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC)
Date of First Priority Issue: Tuesday April 13th, 1993
Patent Number: 6174526
This patent teaches the use of circulating mesenchymal stem cells for treatment of wounds.
Inventors: Cerami, Anthony (Shelter Island, NY); Bucala, Richard J. (New York, NY)
Assignee: The Picower Institute for Medical Research (Manhaset, NY)
Date of First Priority Issue: Friday February 26th, 1993
Patent Number: 5846796
This patent covers mesenchymal stem cells that are circulating in the blood. This patent is interesting since the cells covered contain the hematopoietic stem cell marker CD34, which is usually not believed to be expressed on mesenchymal stem cells. Additionally, the marker CD45, is usually a hematopoietic associated marker, but it too is...
Inventors: Cerami, Anthony (Shelter Island, NY); Bucala, Richard J. (New York, NY)
Assignee: The Picower Institute for Medical Research (Manhasset, NY)
Date of First Priority Issue: Friday February 26th, 1993
Patent Number: 5804446
This patent covers a type of stem cell that circulates and is mesenchymal in nature. The cell phenotype is CD34+ and CD45+, both being markers of hematopoietic and not classical mesenchymal stem cells.
Inventors: Cerami, Anthony (Shelter Island, NY); Bucala, Richard J. (New York, NY)
Assignee: The Picower Institute for Medical Research (Manhasset, NY)
Date of First Priority Issue: Friday February 26th, 1993
Patent Number: 5654186
This patent covers a special population of stem cells that circulate in peripheral blood. Although the patent uses the word "mesenchymal" to describe the cells, these may not be true mesenchymal cells since they possess hematopoietic markers such as CD34 and CD45.
Inventors: Cerami, Anthony (Shelter Island, NY); Bucala, Richard J. (New York, NY)
Assignee: The Picower Institute for Medical Research (Manhasset, NY)
Date of First Priority Issue: Friday February 26th, 1993
Patent Number: 6194202
This patent covers the generation of embryonic stem cells through parthenogenesis in cows. Parthenogenesis involves activating the oocyte to differentiate in absence of sperm.
Inventors: Susko-Parrish, Joan L. (Monona, WI); Northey, David L. (Madison, WI); Leibfried-Rutledge, M. Lorraine (Madison, WI); Stice, Steven L. (DeForest, WI)
Assignee: Infigen, Inc. (DeForest, WI)
Date of First Priority Issue: Wednesday February 10th, 1993
Patent Number: 6077710
This patent covers the generation of embryos through virgin birth or parthenogenesis. Essentially if an oocyte is activated through the induction of calcium flux it can generate an embryo-like structure which can be used to derive stem cells.
Inventors: Susko-Parrish, Joan L. (Monona, WI); Northey, David L. (Madison, WI); Leibfried-Rutledge, M. Lorraine (Madison, WI); Stice, Steven L. (DeForest, WI)
Assignee: Infigen, Inc. (Deforest, WI)
Date of First Priority Issue: Wednesday February 10th, 1993
Patent Number: 5496720
Parthenogenesis comes from Greece and essentially means "virgin birth". This patent teaches how to induce parthenogenesis in a bovine oocyte through induction of calcium flux. The induction of parthenogenesis leads to activation of the oocyte and can be used as a method of generating autologous stem cells for woman.
Inventors: Susko-Parrish, Joan L. (Monona, WI); Northey, David L. (Middleton, WI); Leibfried-Rutledge, M. Lorraine (Madison, WI); Stice, Steven L. (DeForest, WI)
Assignee: None Stated
Date of First Priority Issue: Wednesday February 10th, 1993
Patent Number: 5807686
This patent covers an early hematopoietic stem cell that is identified by unique physical characteristics. It is interesting to see how this patent is read in light of other patents dealing with hematopoietic stem cell populations.
Inventors: Wagner, John E. (Plymouth, MN); Lebkowski, Jane S. (Portola Valley, CA)
Assignee: Regents of University of Minnesota (Minneapolis, MN) Rhone-Poulenc Rorer Pharmaceuticals (Collegeville, PA)
Date of First Priority Issue: Monday November 16th, 1992
Patent Number: 5559022
Liver stem cells are very interesting to study, in part because of the very potent regenerative ability of the liver. In this patent a type of liver stem cell is claimed called the "liver reserve cell".
These cells are characterized by ability to be stained by methylene blue and Azure A, adherence, multinucleation, ability to differentated, and specific density on percoll.
Inventors: Naughton, Brian A. (El Cajon, CA); Sibanda, Benson (Oceanside, CA)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday October 9th, 1992