Class: Type (179)
Clonal cultures of primate embryonic stem cells
Patent Number: 7,217,569This patent covers ways to generate "clonal" embryonic stem cell lines. At face value this specification does not seem to offer anything new in comparison to the previous WARF patents.
Isolation and use of solid tumor stem cells
Patent Number: 6984522In the cancer patient it is believed that tumors are actually a heterogeneous population of cells, and that not all the tumor cells have equal proliferative capability. This concept of the "tumor stem cell" maintaining the bulk of the tumor population is very important since many believe that the cells targeted by conventional therapies are not the actual tumor stem cell but derivatives...
Adipose tissue-derived stromal cell that expresses characteristics of a neuronal cell
Patent Number: 7078230This patent is useful for entities interested in neurodegeneration and sources of neural-like cells. The patent is a composition of matter patent on adipose tissue derived cells that are endowed with neural characteristics. The patent has 2 independent claims, the first covers an adipose tissue derived stromal cell that is differentiated to express neuronal phenotypic markers. The second...
Immortalized human stromal cell lines
Patent Number: 6541249This patent covers some stromal cell lines that have been deposited with ATCC. These cell lines are useful for expansion of hematopoietic stem cells since they secrete a variety of different cytokines. I would be interesting to see if they support expansion of other types of stem cells such as neuronal stem cells.
Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
Patent Number: 7037719This patent teaches how to isolate neuronal stem cells from human fetal brain. The stem cells, or I guess more appropriately, "progenitor cells", are isolated based on positive expression of AC133, binding to the antibody 5E12 (don’t know what that is), and negative for CD34 and CD45. The patent has 6...
Cultures of GFAP nestin cells that differentiate to neurons
Patent Number: 7,303,912This patent covers, in its broadest issued claim, a type of stem cell that is useful for the generation of neurons. The cell population covered is a culture of cells expressing glial fibrillary acidic protein and nestin. In some dependent claims the cells may be extracted from the medial ganglionic eminence (MGE) and lateral ganglionic eminence (LGE). This patent is useful if the...
Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation
Patent Number: 6685936In an effort to solidify its IP wall, Osiris decided not only to cover immune suppression by mesenchymal stem cells, but also the ability of mesenchymal stem cells to elicit other immunosuppressive cells. In this patent to ability of mesenchymal stem cells to activate/expand suppressor T cells, and other types of immune suppressor cells is covered.
Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof
Patent Number: 7056734This patent is useful for entities seeking to treat diabetes or other pancreatic abnormalities. The patent has very broad claims, all centered around the ability of GLP and Exendin-4 to induce differentiation of cells into insulin produce or amylase producing cells. The patent has 8 independent claims. The first four claims are directed towards use of
Progenitor cells, methods and uses related thereto
Patent Number: 6946293This patent teachs ways of expanding a certain type of pancreatic progenitor cell through the steps of first extracting pancreatic or ductal cells; second, treating the cells with a preparation comprising epidermal growth factor, a cAMP elevating agent, and a steroid or corticosteroid; and , third harvesting a non-adherent population. The first and second independent claims essentially...
Method for generating immune-compatible cells and tissues using nuclear transfer techniques
Patent Number: 6808704This patent teaches methods of generating stem cells using cloning that match the potential recipient according to HLA phenotype. This patent could be very useful since in essence it describes a method of making stem cells that will not be rejected by the immune system.