Class: Type (183)
Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof
Patent Number:This patent covers the extraction and use of a muscle derived stem cell that is positive for the markers desmin, CD34, flk-1 and M-Cadherin, but does not express the hematopoietic marker CD45 nor c-kit. This cell type is useful for treatment of a variety of disorders associated with muscle degeneration. Although the inventors state that...
Engraftable human neural stem cells
Patent Number: 6528306This patent uses human fetal telencephalon as a source of stem cells that can be implanted and subsequent to implantation actually interdigitate and function in unison with host neurons.
Keratinocyte stem cells
Patent Number: 6485971This patent covers a type of stem cell that gives rise to keratinocytes. These cells can be purified from skin biopsy and used for amplification and generation of numerous other cell types and tissue. One interesting possibility is the use of such keratinocyte stem cells for generation of artificial thymus.
Human lineage committed cell composition with enhanced proliferative potential, biological effector function, or both; methods for obtaining same; and their uses
Patent Number: 6835566This patent teaches the generation of lineage-committed dendritic cell progenitors. This is important since the dendritic cell is a master controller of the immune response, being able to both stimulate responses as well as inhibit them. Dendritic cells can be made to stimulate responses through activation with various cytokines or toll like receptors, whereas they can also suppress responses...
Purified populations of stem cells
Patent Number: 6852533This is a powerful patent that covers essentially the endothelial precursor cell. The importance of endothelial precursors is their ability to induce angiogenesis. The patent has claims on any CD34 + VEGF R+ cell, as well as CD133+, VEGF R+ endothelial stem cell. Sources of these...
Pluripotential bone marrow cell line and methods of using the same
Patent Number: 6082364This patent seems to cover a cell that is very similar to the cell covered by Osiris...that is mesenchymal stem cells.
Human embryonic germ cell line and methods of use
Patent Number: 6245566This patent covers human primordial germ stem cells. These cells can be used for generating a variety of different stem cell lines, as well as for in vitro generation of various germ cells.
Hematopoietic stem cells
Patent Number: 6537807This patent is in competition with other composition of matter patents that cover hematopoietic stem cells. Specific phenotypes are covered by this patent, which may be the reason why it issued in light of several other patents that also cover similar phenotypes and activities.
Lineage restricted glial precursors from the central nervous system
Patent Number: 6900054Glial cells performed numerous functions in the nervous system including providing support, nutrition, and form myelin for neurons. They represent 90% of the cells in the central nervous system. The ability to generate glial cells ex vivo is critical not only for the potential of administering such cells to damaged areas, but also for using these cells are vectors to carry genes in order to...
Human bone accessory cells
Patent Number: 6576465This patent covers a type of stem cell, or actually a cell that helps bone generating stem cells to perform their function. Therapeutic applications of this cell range from in vitro expansion of bone stem cells, to in vivo induction of bone regeneration.