Class: 3D Culture/Scaffold (88)
Bioartificial device for the storage, cultivation and/or multiplication of cells
Patent Number: 7067307This invention is useful for generating artificial tissue, particularly, but not limited to hepatocytes using a flow-through bioreactor that has the following advantages over the existing technologies: a) Cells can be cultivated; b) Cell growth is under extremely low shear forces and turbulences; c) A continuous supply of oxygen-saturated nutrient medium is provided; and d) Continuous...
Biological scaffolding material
Patent Number: 7,319,035There are numerous patents issued on generation of scaffolds for the implantation of cells into a host in need of therapy. For example, Ethicon's patent 7,091,191 teaches the generation of hydrophobic polymers of hyaluronic acid that are superior to previous hyaluronic acid compositions since the the hydrophobicity extends the...
Cell-scaffold composition containing five layers
Patent Number: 6995013This invention is a 5-layer scaffold that is useful for growing cells in a bioreactor, or in vivo to produce functional vascularized organ tissue. The invention primarily deals with generation of bone tissue, but other types of tissues and organs can be generated using this scaffold. The patent has 1 independent claim which covers the composition of the scaffold. The assignee, Biomed...
Scaffold and method for implanting cells
Patent Number: 7,299,805As more and more becomes known regarding stem cell extraction, differentiation, and manipulation, the value of scaffolding and delivery technologies will increase. The current patent addresses a new way of inserting stem cells into a host through the use of scaffolds derived from bacterial biofilm. Essentially the patent covers various polysaccharide biofilms for generation of structures that...
Bioartificial liver system
Patent Number: 7,160,719This patent covers the use of spheroid hepatocytes and hepatocyte progenitors in liquid culture, in such a manner that they may function as a bioartificial liver. Specifically, the patent teaches that previous artificial liver approaches had certain limitations that did not allow maximal growth and function of hepatocytes ex vivo. The current invention provides various medical device...
Silica-calcium phosphate bioactive composite for improved synthetic graft resorbability and tissue regeneration
Patent Number: 7,223,414Delivery of growth factors along with stem cells is an important component of therapeutic regeneration. The current patent describes new resorbable silica-calcium phosphate bioactive composites that are useful for delayed release of various pharmaceuticals, including growth factors. Potential growth factors useful with this invention include administration of G-CSF with stem cells locally...
Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering
Patent Number: 7049139There are two types of stem cells associated with the outside part of the eye…the limbal stem cells and the conjunctival stem cells. This patent teaches ways of culturing conjunctival stem cells, using various ex vivo tissue culture scenarious, including specialized culture conditions. There is one independent claim, which covers the basic aspects of these conditions. The patent is useful...
Cell delivery patch for myocardial tissue engineering
Patent Number: 7,396,537Various types of stem cell therapeutics are being attempted for cardiac conditions. On the one hand, it is known that infarcts induce mobilization of stem cells, and that this may be part of an endogenous regenerative response. Accordingly, the intravenous administration of mesenchymal stem cells has demonstrated a regenerative...
Hedgehog signaling promotes the formation of three dimensional cartilage matrices
Patent Number: 7,160,725It is known that hedgehog proteins are involved in pattern specification during embryogenesis. The possibility of modulating the hedgehog signalling pathway for regulation of stem cell activity was previously patented for hematopoietic stem cells, neural stem cells and...
Cell delivery system comprising a fibrous matrix and cells
Patent Number: 7,323,190The current patent covers the delivery of cells using a matrix that is fibrous and the fibers are between 10 nanometers to 1 micrometer in diameter. The fibers are made in such a manner so that they are in contact with the cells. In some of the claims the fibers are comprised of polymers, one type of polymer covered is a linear aliphatic polyester. A specific type of linear aliphatic...